Experience in the diagnosis and treatment of pneumonia caused by infection with Tropheryma whipplei: A case series

Tropheryma whipplei (TW) is the root cause of Whipple’s disease (WD), a rare infectious illness leading to multi-organ impairment. A prominent feature of WD is acute pneumonia, which can be exceedingly challenging to diagnose clinically due to the pathogen’s surreptitious nature. However and signifi...

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Detalles Bibliográficos
Autores principales: Fang, Zhixiong, Liu, Qiong, Tang, Wei, Yu, Hongyin, Zou, Min, Zhang, Haiming, Xue, Haiyan, Lin, Sha, Pei, Yi, Ai, Jingwen, Chen, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361318/
https://www.ncbi.nlm.nih.gov/pubmed/37484369
http://dx.doi.org/10.1016/j.heliyon.2023.e17132
Descripción
Sumario:Tropheryma whipplei (TW) is the root cause of Whipple’s disease (WD), a rare infectious illness leading to multi-organ impairment. A prominent feature of WD is acute pneumonia, which can be exceedingly challenging to diagnose clinically due to the pathogen’s surreptitious nature. However and significantly, with the advent of metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid (BALF), it offers clinicians a potent tool at their disposal to detect TW infections. The present study conducted a retrospective analysis of clinical data gleaned from five patients in Hunan Province in China. Findings in this study demonstrated the potential of BALF-mNGS in diagnosing pneumonia caused by TW infection.

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