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Association of triglyceride levels with adverse cardiovascular events in patients with ST-segment elevation myocardial infarction
Although there is an established association between elevated triglyceride (eTG, ≥175 mg/dl) levels and adverse cardiovascular events, some studies have suggested that eTG levels may be linked to neutral or even improved clinical outcomes, particularly among patients with acute myocardial infarction...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361356/ https://www.ncbi.nlm.nih.gov/pubmed/37484361 http://dx.doi.org/10.1016/j.heliyon.2023.e17308 |
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author | Yildiz, Mehmet Miedema, Michael D. Murthy, Avinash Henry, Timothy D. Bergstedt, Seth Okeson, Brynn K. Schmidt, Christian W. Volpenhein, Lucas Garcia, Santiago Sharkey, Scott W. Aguirre, Frank V. |
author_facet | Yildiz, Mehmet Miedema, Michael D. Murthy, Avinash Henry, Timothy D. Bergstedt, Seth Okeson, Brynn K. Schmidt, Christian W. Volpenhein, Lucas Garcia, Santiago Sharkey, Scott W. Aguirre, Frank V. |
author_sort | Yildiz, Mehmet |
collection | PubMed |
description | Although there is an established association between elevated triglyceride (eTG, ≥175 mg/dl) levels and adverse cardiovascular events, some studies have suggested that eTG levels may be linked to neutral or even improved clinical outcomes, particularly among patients with acute myocardial infarction. However, these studies had certain limitations, including small sample sizes, heterogeneous study populations, and inadequate statistical adjustments. To address these limitations, we conducted an analysis of 5347 patients with ST-segment elevation myocardial infarction (STEMI) between March 2003 and December 2020, using a prospective registry-based cohort from two large, regional STEMI centers. We used a triglyceride level of 175 mg/dl as the cutoff point for eTG levels. Of the study participants, 24.5% (n = 1312) had eTG levels. These patients were more likely to be younger, male, and have a higher number of cardiovascular risk factors compared to those with low TG levels. Despite these unfavorable cardiovascular risk profiles, patients with eTG levels had lower unadjusted risks of 1-year major adverse cardiac events (MACE) -a composite of myocardial infarction, stroke, and death- than those with low TG levels (8.8% vs. 11%, p = 0.034). However, after adjusting for certain clinical factors and lipid profile, eTG levels were not associated with a lower 1-year MACE (aHR: 1.10 (0.71–1.70), p = 0.7). In conclusion, a quarter of STEMI patients had eTG levels and these patients had comparable long-term cardiovascular outcomes compared to those with low TG levels after controlling for clinical factors and lipid profile. |
format | Online Article Text |
id | pubmed-10361356 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-103613562023-07-22 Association of triglyceride levels with adverse cardiovascular events in patients with ST-segment elevation myocardial infarction Yildiz, Mehmet Miedema, Michael D. Murthy, Avinash Henry, Timothy D. Bergstedt, Seth Okeson, Brynn K. Schmidt, Christian W. Volpenhein, Lucas Garcia, Santiago Sharkey, Scott W. Aguirre, Frank V. Heliyon Research Article Although there is an established association between elevated triglyceride (eTG, ≥175 mg/dl) levels and adverse cardiovascular events, some studies have suggested that eTG levels may be linked to neutral or even improved clinical outcomes, particularly among patients with acute myocardial infarction. However, these studies had certain limitations, including small sample sizes, heterogeneous study populations, and inadequate statistical adjustments. To address these limitations, we conducted an analysis of 5347 patients with ST-segment elevation myocardial infarction (STEMI) between March 2003 and December 2020, using a prospective registry-based cohort from two large, regional STEMI centers. We used a triglyceride level of 175 mg/dl as the cutoff point for eTG levels. Of the study participants, 24.5% (n = 1312) had eTG levels. These patients were more likely to be younger, male, and have a higher number of cardiovascular risk factors compared to those with low TG levels. Despite these unfavorable cardiovascular risk profiles, patients with eTG levels had lower unadjusted risks of 1-year major adverse cardiac events (MACE) -a composite of myocardial infarction, stroke, and death- than those with low TG levels (8.8% vs. 11%, p = 0.034). However, after adjusting for certain clinical factors and lipid profile, eTG levels were not associated with a lower 1-year MACE (aHR: 1.10 (0.71–1.70), p = 0.7). In conclusion, a quarter of STEMI patients had eTG levels and these patients had comparable long-term cardiovascular outcomes compared to those with low TG levels after controlling for clinical factors and lipid profile. Elsevier 2023-06-14 /pmc/articles/PMC10361356/ /pubmed/37484361 http://dx.doi.org/10.1016/j.heliyon.2023.e17308 Text en © 2023 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Yildiz, Mehmet Miedema, Michael D. Murthy, Avinash Henry, Timothy D. Bergstedt, Seth Okeson, Brynn K. Schmidt, Christian W. Volpenhein, Lucas Garcia, Santiago Sharkey, Scott W. Aguirre, Frank V. Association of triglyceride levels with adverse cardiovascular events in patients with ST-segment elevation myocardial infarction |
title | Association of triglyceride levels with adverse cardiovascular events in patients with ST-segment elevation myocardial infarction |
title_full | Association of triglyceride levels with adverse cardiovascular events in patients with ST-segment elevation myocardial infarction |
title_fullStr | Association of triglyceride levels with adverse cardiovascular events in patients with ST-segment elevation myocardial infarction |
title_full_unstemmed | Association of triglyceride levels with adverse cardiovascular events in patients with ST-segment elevation myocardial infarction |
title_short | Association of triglyceride levels with adverse cardiovascular events in patients with ST-segment elevation myocardial infarction |
title_sort | association of triglyceride levels with adverse cardiovascular events in patients with st-segment elevation myocardial infarction |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361356/ https://www.ncbi.nlm.nih.gov/pubmed/37484361 http://dx.doi.org/10.1016/j.heliyon.2023.e17308 |
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