Rev1 deficiency induces a metabolic shift in MEFs that can be manipulated by the NAD(+) precursor nicotinamide riboside

Replication stress, caused by Rev1 deficiency, is associated with mitochondrial dysfunction, and metabolic stress. However, the overall metabolic alterations and possible interventions to rescue the deficits due to Rev1 loss remain unclear. Here, we report that loss of Rev1 leads to intense changes...

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Detalles Bibliográficos
Autores principales: Anugula, Sharath, Li, Zhiquan, Li, Yuan, Hendriksen, Alexander, Christensen, Peter Bjarn, Wang, Lin, Monk, Jonathan M., de Wind, Niels, Bohr, Vilhelm A., Desler, Claus, Naviaux, Robert K., Rasmussen, Lene Juel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361373/
https://www.ncbi.nlm.nih.gov/pubmed/37484291
http://dx.doi.org/10.1016/j.heliyon.2023.e17392

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