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Women’s views about current and future management of Ductal Carcinoma in Situ (DCIS): A mixed-methods study

Management of low-risk ductal carcinoma in situ (DCIS) is controversial, with clinical trials currently assessing the safety of active monitoring amidst concern about overtreatment. Little is known about general community views regarding DCIS and its management. We aimed to explore women’s understan...

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Autores principales: Nickel, Brooke, McCaffery, Kirsten, Jansen, Jesse, Barratt, Alexandra, Houssami, Nehmat, Saunders, Christobel, Spillane, Andrew, Rutherford, Claudia, Stuart, Kirsty, Robertson, Geraldine, Dixon, Ann, Hersch, Jolyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361483/
https://www.ncbi.nlm.nih.gov/pubmed/37478123
http://dx.doi.org/10.1371/journal.pone.0288972
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author Nickel, Brooke
McCaffery, Kirsten
Jansen, Jesse
Barratt, Alexandra
Houssami, Nehmat
Saunders, Christobel
Spillane, Andrew
Rutherford, Claudia
Stuart, Kirsty
Robertson, Geraldine
Dixon, Ann
Hersch, Jolyn
author_facet Nickel, Brooke
McCaffery, Kirsten
Jansen, Jesse
Barratt, Alexandra
Houssami, Nehmat
Saunders, Christobel
Spillane, Andrew
Rutherford, Claudia
Stuart, Kirsty
Robertson, Geraldine
Dixon, Ann
Hersch, Jolyn
author_sort Nickel, Brooke
collection PubMed
description Management of low-risk ductal carcinoma in situ (DCIS) is controversial, with clinical trials currently assessing the safety of active monitoring amidst concern about overtreatment. Little is known about general community views regarding DCIS and its management. We aimed to explore women’s understanding and views about low-risk DCIS and current and potential future management options. This mixed-method study involved qualitative focus groups and brief quantitative questionnaires. Participants were screening-aged (50–74 years) women, with diverse socioeconomic backgrounds and no personal history of breast cancer/DCIS, recruited from across metropolitan Sydney, Australia. Sessions incorporated an informative presentation interspersed with group discussions which were audio-recorded, transcribed and analysed thematically. Fifty-six women took part in six age-stratified focus groups. Prior awareness of DCIS was limited, however women developed reasonable understanding of DCIS and the relevant issues. Overall, women expressed substantial support for active monitoring being offered as a management approach for low-risk DCIS, and many were interested in participating in a hypothetical clinical trial. Although some women expressed concern that current management may sometimes represent overtreatment, there were mixed views about personally accepting monitoring. Women noted a number of important questions and considerations that would factor into their decision making. Our findings about women’s perceptions of active monitoring for DCIS are timely while results of ongoing clinical trials of monitoring are awaited, and may inform clinicians and investigators designing future, similar trials. Exploration of offering well-informed patients the choice of non-surgical management of low-risk DCIS, even outside a clinical trial setting, may be warranted.
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spelling pubmed-103614832023-07-22 Women’s views about current and future management of Ductal Carcinoma in Situ (DCIS): A mixed-methods study Nickel, Brooke McCaffery, Kirsten Jansen, Jesse Barratt, Alexandra Houssami, Nehmat Saunders, Christobel Spillane, Andrew Rutherford, Claudia Stuart, Kirsty Robertson, Geraldine Dixon, Ann Hersch, Jolyn PLoS One Research Article Management of low-risk ductal carcinoma in situ (DCIS) is controversial, with clinical trials currently assessing the safety of active monitoring amidst concern about overtreatment. Little is known about general community views regarding DCIS and its management. We aimed to explore women’s understanding and views about low-risk DCIS and current and potential future management options. This mixed-method study involved qualitative focus groups and brief quantitative questionnaires. Participants were screening-aged (50–74 years) women, with diverse socioeconomic backgrounds and no personal history of breast cancer/DCIS, recruited from across metropolitan Sydney, Australia. Sessions incorporated an informative presentation interspersed with group discussions which were audio-recorded, transcribed and analysed thematically. Fifty-six women took part in six age-stratified focus groups. Prior awareness of DCIS was limited, however women developed reasonable understanding of DCIS and the relevant issues. Overall, women expressed substantial support for active monitoring being offered as a management approach for low-risk DCIS, and many were interested in participating in a hypothetical clinical trial. Although some women expressed concern that current management may sometimes represent overtreatment, there were mixed views about personally accepting monitoring. Women noted a number of important questions and considerations that would factor into their decision making. Our findings about women’s perceptions of active monitoring for DCIS are timely while results of ongoing clinical trials of monitoring are awaited, and may inform clinicians and investigators designing future, similar trials. Exploration of offering well-informed patients the choice of non-surgical management of low-risk DCIS, even outside a clinical trial setting, may be warranted. Public Library of Science 2023-07-21 /pmc/articles/PMC10361483/ /pubmed/37478123 http://dx.doi.org/10.1371/journal.pone.0288972 Text en © 2023 Nickel et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Nickel, Brooke
McCaffery, Kirsten
Jansen, Jesse
Barratt, Alexandra
Houssami, Nehmat
Saunders, Christobel
Spillane, Andrew
Rutherford, Claudia
Stuart, Kirsty
Robertson, Geraldine
Dixon, Ann
Hersch, Jolyn
Women’s views about current and future management of Ductal Carcinoma in Situ (DCIS): A mixed-methods study
title Women’s views about current and future management of Ductal Carcinoma in Situ (DCIS): A mixed-methods study
title_full Women’s views about current and future management of Ductal Carcinoma in Situ (DCIS): A mixed-methods study
title_fullStr Women’s views about current and future management of Ductal Carcinoma in Situ (DCIS): A mixed-methods study
title_full_unstemmed Women’s views about current and future management of Ductal Carcinoma in Situ (DCIS): A mixed-methods study
title_short Women’s views about current and future management of Ductal Carcinoma in Situ (DCIS): A mixed-methods study
title_sort women’s views about current and future management of ductal carcinoma in situ (dcis): a mixed-methods study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361483/
https://www.ncbi.nlm.nih.gov/pubmed/37478123
http://dx.doi.org/10.1371/journal.pone.0288972
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