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A multilevel account of hippocampal function in spatial and concept learning: Bridging models of behavior and neural assemblies
A complete neuroscience requires multilevel theories that address phenomena ranging from higher-level cognitive behaviors to activities within a cell. We propose an extension to the level of mechanism approach where a computational model of cognition sits in between behavior and brain: It explains t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Association for the Advancement of Science
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361583/ https://www.ncbi.nlm.nih.gov/pubmed/37478189 http://dx.doi.org/10.1126/sciadv.ade6903 |
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author | Mok, Robert M. Love, Bradley C. |
author_facet | Mok, Robert M. Love, Bradley C. |
author_sort | Mok, Robert M. |
collection | PubMed |
description | A complete neuroscience requires multilevel theories that address phenomena ranging from higher-level cognitive behaviors to activities within a cell. We propose an extension to the level of mechanism approach where a computational model of cognition sits in between behavior and brain: It explains the higher-level behavior and can be decomposed into lower-level component mechanisms to provide a richer understanding of the system than any level alone. Toward this end, we decomposed a cognitive model into neuron-like units using a neural flocking approach that parallels recurrent hippocampal activity. Neural flocking coordinates units that collectively form higher-level mental constructs. The decomposed model suggested how brain-scale neural populations coordinate to form assemblies encoding concept and spatial representations and why so many neurons are needed for robust performance at the cognitive level. This multilevel explanation provides a way to understand how cognition and symbol-like representations are supported by coordinated neural populations (assemblies) formed through learning. |
format | Online Article Text |
id | pubmed-10361583 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-103615832023-07-22 A multilevel account of hippocampal function in spatial and concept learning: Bridging models of behavior and neural assemblies Mok, Robert M. Love, Bradley C. Sci Adv Neuroscience A complete neuroscience requires multilevel theories that address phenomena ranging from higher-level cognitive behaviors to activities within a cell. We propose an extension to the level of mechanism approach where a computational model of cognition sits in between behavior and brain: It explains the higher-level behavior and can be decomposed into lower-level component mechanisms to provide a richer understanding of the system than any level alone. Toward this end, we decomposed a cognitive model into neuron-like units using a neural flocking approach that parallels recurrent hippocampal activity. Neural flocking coordinates units that collectively form higher-level mental constructs. The decomposed model suggested how brain-scale neural populations coordinate to form assemblies encoding concept and spatial representations and why so many neurons are needed for robust performance at the cognitive level. This multilevel explanation provides a way to understand how cognition and symbol-like representations are supported by coordinated neural populations (assemblies) formed through learning. American Association for the Advancement of Science 2023-07-21 /pmc/articles/PMC10361583/ /pubmed/37478189 http://dx.doi.org/10.1126/sciadv.ade6903 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Neuroscience Mok, Robert M. Love, Bradley C. A multilevel account of hippocampal function in spatial and concept learning: Bridging models of behavior and neural assemblies |
title | A multilevel account of hippocampal function in spatial and concept learning: Bridging models of behavior and neural assemblies |
title_full | A multilevel account of hippocampal function in spatial and concept learning: Bridging models of behavior and neural assemblies |
title_fullStr | A multilevel account of hippocampal function in spatial and concept learning: Bridging models of behavior and neural assemblies |
title_full_unstemmed | A multilevel account of hippocampal function in spatial and concept learning: Bridging models of behavior and neural assemblies |
title_short | A multilevel account of hippocampal function in spatial and concept learning: Bridging models of behavior and neural assemblies |
title_sort | multilevel account of hippocampal function in spatial and concept learning: bridging models of behavior and neural assemblies |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361583/ https://www.ncbi.nlm.nih.gov/pubmed/37478189 http://dx.doi.org/10.1126/sciadv.ade6903 |
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