Cargando…

A multilevel account of hippocampal function in spatial and concept learning: Bridging models of behavior and neural assemblies

A complete neuroscience requires multilevel theories that address phenomena ranging from higher-level cognitive behaviors to activities within a cell. We propose an extension to the level of mechanism approach where a computational model of cognition sits in between behavior and brain: It explains t...

Descripción completa

Detalles Bibliográficos
Autores principales: Mok, Robert M., Love, Bradley C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361583/
https://www.ncbi.nlm.nih.gov/pubmed/37478189
http://dx.doi.org/10.1126/sciadv.ade6903
_version_ 1785076249042878464
author Mok, Robert M.
Love, Bradley C.
author_facet Mok, Robert M.
Love, Bradley C.
author_sort Mok, Robert M.
collection PubMed
description A complete neuroscience requires multilevel theories that address phenomena ranging from higher-level cognitive behaviors to activities within a cell. We propose an extension to the level of mechanism approach where a computational model of cognition sits in between behavior and brain: It explains the higher-level behavior and can be decomposed into lower-level component mechanisms to provide a richer understanding of the system than any level alone. Toward this end, we decomposed a cognitive model into neuron-like units using a neural flocking approach that parallels recurrent hippocampal activity. Neural flocking coordinates units that collectively form higher-level mental constructs. The decomposed model suggested how brain-scale neural populations coordinate to form assemblies encoding concept and spatial representations and why so many neurons are needed for robust performance at the cognitive level. This multilevel explanation provides a way to understand how cognition and symbol-like representations are supported by coordinated neural populations (assemblies) formed through learning.
format Online
Article
Text
id pubmed-10361583
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher American Association for the Advancement of Science
record_format MEDLINE/PubMed
spelling pubmed-103615832023-07-22 A multilevel account of hippocampal function in spatial and concept learning: Bridging models of behavior and neural assemblies Mok, Robert M. Love, Bradley C. Sci Adv Neuroscience A complete neuroscience requires multilevel theories that address phenomena ranging from higher-level cognitive behaviors to activities within a cell. We propose an extension to the level of mechanism approach where a computational model of cognition sits in between behavior and brain: It explains the higher-level behavior and can be decomposed into lower-level component mechanisms to provide a richer understanding of the system than any level alone. Toward this end, we decomposed a cognitive model into neuron-like units using a neural flocking approach that parallels recurrent hippocampal activity. Neural flocking coordinates units that collectively form higher-level mental constructs. The decomposed model suggested how brain-scale neural populations coordinate to form assemblies encoding concept and spatial representations and why so many neurons are needed for robust performance at the cognitive level. This multilevel explanation provides a way to understand how cognition and symbol-like representations are supported by coordinated neural populations (assemblies) formed through learning. American Association for the Advancement of Science 2023-07-21 /pmc/articles/PMC10361583/ /pubmed/37478189 http://dx.doi.org/10.1126/sciadv.ade6903 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Neuroscience
Mok, Robert M.
Love, Bradley C.
A multilevel account of hippocampal function in spatial and concept learning: Bridging models of behavior and neural assemblies
title A multilevel account of hippocampal function in spatial and concept learning: Bridging models of behavior and neural assemblies
title_full A multilevel account of hippocampal function in spatial and concept learning: Bridging models of behavior and neural assemblies
title_fullStr A multilevel account of hippocampal function in spatial and concept learning: Bridging models of behavior and neural assemblies
title_full_unstemmed A multilevel account of hippocampal function in spatial and concept learning: Bridging models of behavior and neural assemblies
title_short A multilevel account of hippocampal function in spatial and concept learning: Bridging models of behavior and neural assemblies
title_sort multilevel account of hippocampal function in spatial and concept learning: bridging models of behavior and neural assemblies
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361583/
https://www.ncbi.nlm.nih.gov/pubmed/37478189
http://dx.doi.org/10.1126/sciadv.ade6903
work_keys_str_mv AT mokrobertm amultilevelaccountofhippocampalfunctioninspatialandconceptlearningbridgingmodelsofbehaviorandneuralassemblies
AT lovebradleyc amultilevelaccountofhippocampalfunctioninspatialandconceptlearningbridgingmodelsofbehaviorandneuralassemblies
AT mokrobertm multilevelaccountofhippocampalfunctioninspatialandconceptlearningbridgingmodelsofbehaviorandneuralassemblies
AT lovebradleyc multilevelaccountofhippocampalfunctioninspatialandconceptlearningbridgingmodelsofbehaviorandneuralassemblies