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Citizen science reveals landscape-scale exposures to multiazole-resistant Aspergillus fumigatus bioaerosols
Using a citizen science approach, we identify a country-wide exposure to aerosolized spores of a human fungal pathogen, Aspergillus fumigatus, that has acquired resistance to the agricultural fungicide tebuconazole and first-line azole clinical antifungal drugs. Genomic analysis shows no distinction...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361594/ https://www.ncbi.nlm.nih.gov/pubmed/37478175 http://dx.doi.org/10.1126/sciadv.adh8839 |
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author | Shelton, Jennifer M. G. Rhodes, Johanna Uzzell, Christopher B. Hemmings, Samuel Brackin, Amelie P. Sewell, Thomas R. Alghamdi, Asmaa Dyer, Paul S. Fraser, Mark Borman, Andrew M. Johnson, Elizabeth M. Piel, Frédéric B. Singer, Andrew C. Fisher, Matthew C. |
author_facet | Shelton, Jennifer M. G. Rhodes, Johanna Uzzell, Christopher B. Hemmings, Samuel Brackin, Amelie P. Sewell, Thomas R. Alghamdi, Asmaa Dyer, Paul S. Fraser, Mark Borman, Andrew M. Johnson, Elizabeth M. Piel, Frédéric B. Singer, Andrew C. Fisher, Matthew C. |
author_sort | Shelton, Jennifer M. G. |
collection | PubMed |
description | Using a citizen science approach, we identify a country-wide exposure to aerosolized spores of a human fungal pathogen, Aspergillus fumigatus, that has acquired resistance to the agricultural fungicide tebuconazole and first-line azole clinical antifungal drugs. Genomic analysis shows no distinction between resistant genotypes found in the environment and in patients, indicating that at least 40% of azole-resistant A. fumigatus infections are acquired from environmental exposures. Hotspots and coldspots of aerosolized azole-resistant spores were not stable between seasonal sampling periods. This suggests a high degree of atmospheric mixing resulting in an estimated per capita cumulative annual exposure of 21 days (±2.6). Because of the ubiquity of this measured exposure, it is imperative that we determine sources of azole-resistant A. fumigatus to reduce treatment failure in patients with aspergillosis. |
format | Online Article Text |
id | pubmed-10361594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-103615942023-07-22 Citizen science reveals landscape-scale exposures to multiazole-resistant Aspergillus fumigatus bioaerosols Shelton, Jennifer M. G. Rhodes, Johanna Uzzell, Christopher B. Hemmings, Samuel Brackin, Amelie P. Sewell, Thomas R. Alghamdi, Asmaa Dyer, Paul S. Fraser, Mark Borman, Andrew M. Johnson, Elizabeth M. Piel, Frédéric B. Singer, Andrew C. Fisher, Matthew C. Sci Adv Social and Interdisciplinary Sciences Using a citizen science approach, we identify a country-wide exposure to aerosolized spores of a human fungal pathogen, Aspergillus fumigatus, that has acquired resistance to the agricultural fungicide tebuconazole and first-line azole clinical antifungal drugs. Genomic analysis shows no distinction between resistant genotypes found in the environment and in patients, indicating that at least 40% of azole-resistant A. fumigatus infections are acquired from environmental exposures. Hotspots and coldspots of aerosolized azole-resistant spores were not stable between seasonal sampling periods. This suggests a high degree of atmospheric mixing resulting in an estimated per capita cumulative annual exposure of 21 days (±2.6). Because of the ubiquity of this measured exposure, it is imperative that we determine sources of azole-resistant A. fumigatus to reduce treatment failure in patients with aspergillosis. American Association for the Advancement of Science 2023-07-21 /pmc/articles/PMC10361594/ /pubmed/37478175 http://dx.doi.org/10.1126/sciadv.adh8839 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Social and Interdisciplinary Sciences Shelton, Jennifer M. G. Rhodes, Johanna Uzzell, Christopher B. Hemmings, Samuel Brackin, Amelie P. Sewell, Thomas R. Alghamdi, Asmaa Dyer, Paul S. Fraser, Mark Borman, Andrew M. Johnson, Elizabeth M. Piel, Frédéric B. Singer, Andrew C. Fisher, Matthew C. Citizen science reveals landscape-scale exposures to multiazole-resistant Aspergillus fumigatus bioaerosols |
title | Citizen science reveals landscape-scale exposures to multiazole-resistant Aspergillus fumigatus bioaerosols |
title_full | Citizen science reveals landscape-scale exposures to multiazole-resistant Aspergillus fumigatus bioaerosols |
title_fullStr | Citizen science reveals landscape-scale exposures to multiazole-resistant Aspergillus fumigatus bioaerosols |
title_full_unstemmed | Citizen science reveals landscape-scale exposures to multiazole-resistant Aspergillus fumigatus bioaerosols |
title_short | Citizen science reveals landscape-scale exposures to multiazole-resistant Aspergillus fumigatus bioaerosols |
title_sort | citizen science reveals landscape-scale exposures to multiazole-resistant aspergillus fumigatus bioaerosols |
topic | Social and Interdisciplinary Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361594/ https://www.ncbi.nlm.nih.gov/pubmed/37478175 http://dx.doi.org/10.1126/sciadv.adh8839 |
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