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Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection of vaccinated individuals is increasingly common with the circulation of highly immune evasive and transmissible Omicron variants. Here, we report the dynamics and durability of recalled spike-specific humoral immuni...

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Autores principales: Lee, Wen Shi, Tan, Hyon-Xhi, Reynaldi, Arnold, Esterbauer, Robyn, Koutsakos, Marios, Nguyen, Julie, Amarasena, Thakshila, Kent, Helen E., Aggarwal, Anupriya, Turville, Stuart G., Taiaroa, George, Kinsella, Paul, Liew, Kwee Chin, Tran, Thomas, Williamson, Deborah A., Cromer, Deborah, Davenport, Miles P., Kent, Stephen J., Juno, Jennifer A., Khoury, David S., Wheatley, Adam K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361595/
https://www.ncbi.nlm.nih.gov/pubmed/37478181
http://dx.doi.org/10.1126/sciadv.adg5301
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author Lee, Wen Shi
Tan, Hyon-Xhi
Reynaldi, Arnold
Esterbauer, Robyn
Koutsakos, Marios
Nguyen, Julie
Amarasena, Thakshila
Kent, Helen E.
Aggarwal, Anupriya
Turville, Stuart G.
Taiaroa, George
Kinsella, Paul
Liew, Kwee Chin
Tran, Thomas
Williamson, Deborah A.
Cromer, Deborah
Davenport, Miles P.
Kent, Stephen J.
Juno, Jennifer A.
Khoury, David S.
Wheatley, Adam K.
author_facet Lee, Wen Shi
Tan, Hyon-Xhi
Reynaldi, Arnold
Esterbauer, Robyn
Koutsakos, Marios
Nguyen, Julie
Amarasena, Thakshila
Kent, Helen E.
Aggarwal, Anupriya
Turville, Stuart G.
Taiaroa, George
Kinsella, Paul
Liew, Kwee Chin
Tran, Thomas
Williamson, Deborah A.
Cromer, Deborah
Davenport, Miles P.
Kent, Stephen J.
Juno, Jennifer A.
Khoury, David S.
Wheatley, Adam K.
author_sort Lee, Wen Shi
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection of vaccinated individuals is increasingly common with the circulation of highly immune evasive and transmissible Omicron variants. Here, we report the dynamics and durability of recalled spike-specific humoral immunity following Omicron BA.1 or BA.2 breakthrough infection, with longitudinal sampling up to 8 months after infection. Both BA.1 and BA.2 infections robustly boosted neutralization activity against the infecting strain while expanding breadth against BA.4, although neutralization activity was substantially reduced for the more recent XBB and BQ.1.1 strains. Cross-reactive memory B cells against both ancestral and Omicron spike were predominantly expanded by infection, with limited recruitment of de novo Omicron-specific B cells or antibodies. Modeling of neutralization titers predicts that protection from symptomatic reinfection against antigenically similar strains will be durable but is undermined by new emerging strains with further neutralization escape.
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spelling pubmed-103615952023-07-22 Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection Lee, Wen Shi Tan, Hyon-Xhi Reynaldi, Arnold Esterbauer, Robyn Koutsakos, Marios Nguyen, Julie Amarasena, Thakshila Kent, Helen E. Aggarwal, Anupriya Turville, Stuart G. Taiaroa, George Kinsella, Paul Liew, Kwee Chin Tran, Thomas Williamson, Deborah A. Cromer, Deborah Davenport, Miles P. Kent, Stephen J. Juno, Jennifer A. Khoury, David S. Wheatley, Adam K. Sci Adv Biomedicine and Life Sciences Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection of vaccinated individuals is increasingly common with the circulation of highly immune evasive and transmissible Omicron variants. Here, we report the dynamics and durability of recalled spike-specific humoral immunity following Omicron BA.1 or BA.2 breakthrough infection, with longitudinal sampling up to 8 months after infection. Both BA.1 and BA.2 infections robustly boosted neutralization activity against the infecting strain while expanding breadth against BA.4, although neutralization activity was substantially reduced for the more recent XBB and BQ.1.1 strains. Cross-reactive memory B cells against both ancestral and Omicron spike were predominantly expanded by infection, with limited recruitment of de novo Omicron-specific B cells or antibodies. Modeling of neutralization titers predicts that protection from symptomatic reinfection against antigenically similar strains will be durable but is undermined by new emerging strains with further neutralization escape. American Association for the Advancement of Science 2023-07-21 /pmc/articles/PMC10361595/ /pubmed/37478181 http://dx.doi.org/10.1126/sciadv.adg5301 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Biomedicine and Life Sciences
Lee, Wen Shi
Tan, Hyon-Xhi
Reynaldi, Arnold
Esterbauer, Robyn
Koutsakos, Marios
Nguyen, Julie
Amarasena, Thakshila
Kent, Helen E.
Aggarwal, Anupriya
Turville, Stuart G.
Taiaroa, George
Kinsella, Paul
Liew, Kwee Chin
Tran, Thomas
Williamson, Deborah A.
Cromer, Deborah
Davenport, Miles P.
Kent, Stephen J.
Juno, Jennifer A.
Khoury, David S.
Wheatley, Adam K.
Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection
title Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection
title_full Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection
title_fullStr Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection
title_full_unstemmed Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection
title_short Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection
title_sort durable reprogramming of neutralizing antibody responses following omicron breakthrough infection
topic Biomedicine and Life Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361595/
https://www.ncbi.nlm.nih.gov/pubmed/37478181
http://dx.doi.org/10.1126/sciadv.adg5301
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