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Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection of vaccinated individuals is increasingly common with the circulation of highly immune evasive and transmissible Omicron variants. Here, we report the dynamics and durability of recalled spike-specific humoral immuni...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361595/ https://www.ncbi.nlm.nih.gov/pubmed/37478181 http://dx.doi.org/10.1126/sciadv.adg5301 |
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author | Lee, Wen Shi Tan, Hyon-Xhi Reynaldi, Arnold Esterbauer, Robyn Koutsakos, Marios Nguyen, Julie Amarasena, Thakshila Kent, Helen E. Aggarwal, Anupriya Turville, Stuart G. Taiaroa, George Kinsella, Paul Liew, Kwee Chin Tran, Thomas Williamson, Deborah A. Cromer, Deborah Davenport, Miles P. Kent, Stephen J. Juno, Jennifer A. Khoury, David S. Wheatley, Adam K. |
author_facet | Lee, Wen Shi Tan, Hyon-Xhi Reynaldi, Arnold Esterbauer, Robyn Koutsakos, Marios Nguyen, Julie Amarasena, Thakshila Kent, Helen E. Aggarwal, Anupriya Turville, Stuart G. Taiaroa, George Kinsella, Paul Liew, Kwee Chin Tran, Thomas Williamson, Deborah A. Cromer, Deborah Davenport, Miles P. Kent, Stephen J. Juno, Jennifer A. Khoury, David S. Wheatley, Adam K. |
author_sort | Lee, Wen Shi |
collection | PubMed |
description | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection of vaccinated individuals is increasingly common with the circulation of highly immune evasive and transmissible Omicron variants. Here, we report the dynamics and durability of recalled spike-specific humoral immunity following Omicron BA.1 or BA.2 breakthrough infection, with longitudinal sampling up to 8 months after infection. Both BA.1 and BA.2 infections robustly boosted neutralization activity against the infecting strain while expanding breadth against BA.4, although neutralization activity was substantially reduced for the more recent XBB and BQ.1.1 strains. Cross-reactive memory B cells against both ancestral and Omicron spike were predominantly expanded by infection, with limited recruitment of de novo Omicron-specific B cells or antibodies. Modeling of neutralization titers predicts that protection from symptomatic reinfection against antigenically similar strains will be durable but is undermined by new emerging strains with further neutralization escape. |
format | Online Article Text |
id | pubmed-10361595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-103615952023-07-22 Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection Lee, Wen Shi Tan, Hyon-Xhi Reynaldi, Arnold Esterbauer, Robyn Koutsakos, Marios Nguyen, Julie Amarasena, Thakshila Kent, Helen E. Aggarwal, Anupriya Turville, Stuart G. Taiaroa, George Kinsella, Paul Liew, Kwee Chin Tran, Thomas Williamson, Deborah A. Cromer, Deborah Davenport, Miles P. Kent, Stephen J. Juno, Jennifer A. Khoury, David S. Wheatley, Adam K. Sci Adv Biomedicine and Life Sciences Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection of vaccinated individuals is increasingly common with the circulation of highly immune evasive and transmissible Omicron variants. Here, we report the dynamics and durability of recalled spike-specific humoral immunity following Omicron BA.1 or BA.2 breakthrough infection, with longitudinal sampling up to 8 months after infection. Both BA.1 and BA.2 infections robustly boosted neutralization activity against the infecting strain while expanding breadth against BA.4, although neutralization activity was substantially reduced for the more recent XBB and BQ.1.1 strains. Cross-reactive memory B cells against both ancestral and Omicron spike were predominantly expanded by infection, with limited recruitment of de novo Omicron-specific B cells or antibodies. Modeling of neutralization titers predicts that protection from symptomatic reinfection against antigenically similar strains will be durable but is undermined by new emerging strains with further neutralization escape. American Association for the Advancement of Science 2023-07-21 /pmc/articles/PMC10361595/ /pubmed/37478181 http://dx.doi.org/10.1126/sciadv.adg5301 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Biomedicine and Life Sciences Lee, Wen Shi Tan, Hyon-Xhi Reynaldi, Arnold Esterbauer, Robyn Koutsakos, Marios Nguyen, Julie Amarasena, Thakshila Kent, Helen E. Aggarwal, Anupriya Turville, Stuart G. Taiaroa, George Kinsella, Paul Liew, Kwee Chin Tran, Thomas Williamson, Deborah A. Cromer, Deborah Davenport, Miles P. Kent, Stephen J. Juno, Jennifer A. Khoury, David S. Wheatley, Adam K. Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection |
title | Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection |
title_full | Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection |
title_fullStr | Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection |
title_full_unstemmed | Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection |
title_short | Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection |
title_sort | durable reprogramming of neutralizing antibody responses following omicron breakthrough infection |
topic | Biomedicine and Life Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361595/ https://www.ncbi.nlm.nih.gov/pubmed/37478181 http://dx.doi.org/10.1126/sciadv.adg5301 |
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