Targeting polyploid giant cancer cells potentiates a therapeutic response and overcomes resistance to PARP inhibitors in ovarian cancer

To understand the mechanism of acquired resistance to poly(ADP-ribose) polymerase inhibitors (PARPi) olaparib, we induced the formation of polyploid giant cancer cells (PGCCs) in ovarian and breast cancer cell lines, high-grade serous cancer (HGSC)–derived organoids, and patient-derived xenografts (...

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Detalles Bibliográficos
Autores principales: Zhang, Xudong, Yao, Jun, Li, Xiaoran, Niu, Na, Liu, Yan, Hajek, Richard A., Peng, Guang, Westin, Shannon, Sood, Anil K., Liu, Jinsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361597/
https://www.ncbi.nlm.nih.gov/pubmed/37478190
http://dx.doi.org/10.1126/sciadv.adf7195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361597/
https://www.ncbi.nlm.nih.gov/pubmed/37478190
http://dx.doi.org/10.1126/sciadv.adf7195

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