Cargando…

Targeting polyploid giant cancer cells potentiates a therapeutic response and overcomes resistance to PARP inhibitors in ovarian cancer

To understand the mechanism of acquired resistance to poly(ADP-ribose) polymerase inhibitors (PARPi) olaparib, we induced the formation of polyploid giant cancer cells (PGCCs) in ovarian and breast cancer cell lines, high-grade serous cancer (HGSC)–derived organoids, and patient-derived xenografts (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Xudong, Yao, Jun, Li, Xiaoran, Niu, Na, Liu, Yan, Hajek, Richard A., Peng, Guang, Westin, Shannon, Sood, Anil K., Liu, Jinsong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361597/ https://www.ncbi.nlm.nih.gov/pubmed/37478190 http://dx.doi.org/10.1126/sciadv.adf7195

Ejemplares similares

Spatiotemporal view of malignant histogenesis and macroevolution via formation of polyploid giant cancer cells
por: Li, Xiaoran, et al.
Publicado: (2023)

Clinical PARP inhibitors allosterically induce PARP2 retention on DNA
por: Langelier, Marie-France, et al.
Publicado: (2023)

PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities
por: Đukić, Nina, et al.
Publicado: (2023)

A two-step mechanism governing PARP1-DNA retention by PARP inhibitors
por: Xue, Huijun, et al.
Publicado: (2022)

Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer
por: Li, Peng, et al.
Publicado: (2023)

RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer
por: Miao, Chenkui, et al.
Publicado: (2022)

IL-6 promotes drug resistance through formation of polyploid giant cancer cells and stromal fibroblast reprogramming
por: Niu, Na, et al.
Publicado: (2021)

Targeting HER2-AXL heterodimerization to overcome resistance to HER2 blockade in breast cancer
por: Adam-Artigues, Anna, et al.
Publicado: (2022)

Cancer-associated MSC drive tumor immune exclusion and resistance to immunotherapy, which can be overcome by Hedgehog inhibition
por: Cascio, Sandra, et al.
Publicado: (2021)

Therapeutic targeting of CPSF3-dependent transcriptional termination in ovarian cancer
por: Shen, Peiye, et al.
Publicado: (2023)

Giant proteins in a giant cell: Molecular basis of ultrafast Ca(2+)-dependent cell contraction
por: Zhang, Jing, et al.
Publicado: (2023)

Mitoxantrone targets both host and bacteria to overcome vancomycin resistance in Enterococcus faecalis
por: da Silva, Ronni A. G., et al.
Publicado: (2023)

An implantable ultrasound-powered device for the treatment of brain cancer using electromagnetic fields
por: Yang, Yilin, et al.
Publicado: (2022)

Overcoming differential tumor penetration of BRAF inhibitors using computationally guided combination therapy
por: Ng, Thomas S. C., et al.
Publicado: (2022)

Longitudinal single-cell RNA-seq analysis reveals stress-promoted chemoresistance in metastatic ovarian cancer
por: Zhang, Kaiyang, et al.
Publicado: (2022)

Loss of metabolic fitness drives tumor resistance after CAR-NK cell therapy and can be overcome by cytokine engineering
por: Li, Li, et al.
Publicado: (2023)

Macrophage activation drives ovarian failure and masculinization in zebrafish
por: Bravo, Paloma, et al.
Publicado: (2023)

Enhanced TP53 reactivation disrupts MYC transcriptional program and overcomes venetoclax resistance in acute myeloid leukemias
por: Nishida, Yuki, et al.
Publicado: (2023)

FOXA1 O-GlcNAcylation–mediated transcriptional switch governs metastasis capacity in breast cancer
por: Liu, Yajie, et al.
Publicado: (2023)

Siglec-7 glyco-immune binding mAbs or NK cell engager biologics induce potent antitumor immunity against ovarian cancers
por: Bordoloi, Devivasha, et al.
Publicado: (2023)

Imaging and tracing the pattern of adult ovarian angiogenesis implies a strategy against female reproductive aging
por: Xu, Xueqiang, et al.
Publicado: (2022)

Chronic superphysiologic AMH promotes premature luteinization of antral follicles in human ovarian xenografts
por: Man, Limor, et al.
Publicado: (2022)

Overcoming Platinum and PARP-Inhibitor Resistance in Ovarian Cancer
por: McMullen, Michelle, et al.
Publicado: (2020)

Pore forming–mediated intracellular protein delivery for enhanced cancer immunotherapy
por: Zhou, Zhanwei, et al.
Publicado: (2022)

Coevolution of neoplastic epithelial cells and multilineage stroma via polyploid giant cells during immortalization and transformation of mullerian epithelial cells
por: Zhang, Shiwu, et al.
Publicado: (2016)

Identifying high-grade serous ovarian carcinoma–specific extracellular vesicles by polyketone-coated nanowires
por: Yokoi, Akira, et al.
Publicado: (2023)

Psychological distress and eustress in cancer and cancer treatment: Advances and perspectives
por: Wu, Yuanjun, et al.
Publicado: (2022)

Biological chemotaxis-guided self-thermophoretic nanoplatform augments colorectal cancer therapy through autonomous mucus penetration
por: Wang, Zhi-Hao, et al.
Publicado: (2022)

Targeting metabotropic glutamate receptor 4 for cancer immunotherapy
por: Wan, Zhuoya, et al.
Publicado: (2021)

Comprehensive analysis of spatial architecture in primary liver cancer
por: Wu, Rui, et al.
Publicado: (2021)

Liver cancer heterogeneity modeled by in situ genome editing of hepatocytes
por: Tang, Mei, et al.
Publicado: (2022)

CancerVar: An artificial intelligence–empowered platform for clinical interpretation of somatic mutations in cancer
por: Li, Quan, et al.
Publicado: (2022)

Metallo-alginate hydrogel can potentiate microwave tumor ablation for synergistic cancer treatment
por: Zhu, Yujie, et al.
Publicado: (2022)

Ultrastructural visualization of chromatin in cancer pathogenesis using a simple small-molecule fluorescent probe
por: Xu, Jianquan, et al.
Publicado: (2022)

Cross-species identification of cancer resistance–associated genes that may mediate human cancer risk
por: Nair, Nishanth Ulhas, et al.
Publicado: (2022)

The landscape of cryptic antisense transcription in human cancers reveals an oncogenic noncoding RNA in lung cancer
por: Zhao, Zhaozhao, et al.
Publicado: (2023)

PARP inhibitors in ovarian cancer: overcoming resistance with combination strategies
por: Miller, Rowan E, et al.
Publicado: (2022)

iTRAQ-Based Proteomic Analysis of Polyploid Giant Cancer Cells and Budding Progeny Cells Reveals Several Distinct Pathways for Ovarian Cancer Development
por: Zhang, Shiwu, et al.
Publicado: (2013)

Cell-free DNA TAPS provides multimodal information for early cancer detection
por: Siejka-Zielińska, Paulina, et al.
Publicado: (2021)

More than bad luck: Cancer and aging are linked to replication-driven changes to the epigenome
por: Minteer, Christopher J., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_7ivlq150gge7f8u0ll39evfldt