Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammation

Variants in genes encoding the soluble guanylyl cyclase (sGC) in platelets are associated with coronary artery disease (CAD) risk. Here, by using histology, flow cytometry and intravital microscopy, we show that functional loss of sGC in platelets of atherosclerosis-prone Ldlr(−/−) mice contributes...

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Detalles Bibliográficos
Autores principales: Mauersberger, Carina, Sager, Hendrik B., Wobst, Jana, Dang, Tan An, Lambrecht, Laura, Koplev, Simon, Stroth, Marlène, Bettaga, Noomen, Schlossmann, Jens, Wunder, Frank, Friebe, Andreas, Björkegren, Johan L. M., Dietz, Lisa, Maas, Sanne L., van der Vorst, Emiel P. C., Sandner, Peter, Soehnlein, Oliver, Schunkert, Heribert, Kessler, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361702/
https://www.ncbi.nlm.nih.gov/pubmed/37484062
http://dx.doi.org/10.1038/s44161-022-00175-w

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