Cargando…

Investigating potential immune mechanisms of trilaciclib administered prior to chemotherapy in patients with metastatic triple-negative breast cancer

PURPOSE: In a phase II trial in patients with metastatic triple-negative breast cancer (mTNBC; NCT02978716), administering trilaciclib prior to gemcitabine plus carboplatin (GCb) enhanced T-cell activation and improved overall survival versus GCb alone. The survival benefit was more pronounced in pa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tan, Antoinette R., O’Shaughnessy, Joyce, Cao, Subing, Ahn, Sarah, Yi, John S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2023
Materias:	Original Laboratory Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361859/ https://www.ncbi.nlm.nih.gov/pubmed/37418031 http://dx.doi.org/10.1007/s10549-023-07009-8

Ejemplares similares

Trilaciclib Prior to Chemotherapy in Patients with Metastatic Triple-Negative Breast Cancer: Final Efficacy and Subgroup Analysis from a Randomized Phase II Study
por: Tan, Antoinette R., et al.
Publicado: (2022)

Overexpressions of Vimentin and Integrins in Human Metastatic Spine Tumors
por: Park, Sung Bae, et al.
Publicado: (2015)

The hedgehog pathway in triple‐negative breast cancer
por: Habib, Joyce G., et al.
Publicado: (2016)

Lower expression of Bax predicts poor clinical outcome in patients with glioma after curative resection and radiotherapy/chemotherapy
por: Wang, Pei-Guo, et al.
Publicado: (2018)

Investigating the Potential of Lipids for Use as Biomarkers for Glioblastoma via an Untargeted Lipidomics Approach
por: Soylemez, Burcak, et al.
Publicado: (2023)

Combination chemotherapy versus temozolomide for patients with methylated MGMT (m-MGMT) glioblastoma: results of computational biological modeling to predict the magnitude of treatment benefit
por: Castro, Michael, et al.
Publicado: (2021)

Drug loss from Paclitaxel-Coated Balloons During Preparation, Insertion and Inflation for Angioplasty: A Laboratory Investigation
por: Faenger, Bernd, et al.
Publicado: (2022)

Phantom Study Investigating the Accuracy of Manual and Automatic Image Fusion with the GE Logiq E9: Implications for use in Percutaneous Liver Interventions
por: Burgmans, Mark Christiaan, et al.
Publicado: (2017)

An Experimental Study on the Biomechanical Effectiveness of Bone Cement-Augmented Pedicle Screw Fixation with Various Types of Fenestrations
por: Yoon, Sang Hoon, et al.
Publicado: (2022)

Profiling of T Cell Receptor β-Chain Complimentary Determining Regions 3 Repertoire in Subarachnoid Hemorrhage Patients Using High-Throughput Sequencing
por: Kim, Bong Jun, et al.
Publicado: (2021)

Fucosyltransferase 4 and 7 mediates adhesion of non-small cell lung cancer cells to brain-derived endothelial cells and results in modification of the blood–brain-barrier: in vitro investigation of CD15 and CD15s in lung-to-brain metastasis
por: Jassam, Samah A., et al.
Publicado: (2019)

Neuroprotective Effects of Sacral Epidural Neuromodulation Following Spinal Cord Injury : An Experimental Study in Rats
por: Lee, Chang-Hyun, et al.
Publicado: (2012)

The Effect of GCSB-5 a New Herbal Medicine on Changes in Pain Behavior and Neuroglial Activation in a Rat Model of Lumbar Disc Herniation
por: Cho, Hee Kyung, et al.
Publicado: (2016)

Nerve Growth Factor Stimulates Glioblastoma Proliferation through Notch1 Receptor Signaling
por: Park, Jun Chul, et al.
Publicado: (2018)

Reversal of the Pathophysiological Responses to Gram-Negative Sepsis by Megadose Vitamin C
por: Lankadeva, Yugeesh R., et al.
Publicado: (2020)

Baseline interleukin-6 is a prognostic factor for patients with metastatic breast cancer treated with eribulin
por: Bun, Ayako, et al.
Publicado: (2023)

Carotid Artery Stenting Using a Novel Self-Expanding Braided Nickel–Titanium Stent: Feasibility and Safety Porcine Trial
por: Ahlhelm, Frank, et al.
Publicado: (2009)

Biocompatibility, Inflammatory Response, and Recannalization Characteristics of Nonradioactive Resin Microspheres: Histological Findings
por: Bilbao, José I., et al.
Publicado: (2009)

The Neuroprotective Effect of Treatment of Valproic Acid in Acute Spinal Cord Injury
por: Yu, Song-Hee, et al.
Publicado: (2012)

Baroreflex sensitivity differs among same strain Wistar rats from the same laboratory
por: Valenti, Vitor E., et al.
Publicado: (2011)

A Novel Mechanical Thrombectomy Device for Retrieval of Intravascular Thrombus
por: Monsky, Wayne L., et al.
Publicado: (2010)

Histomorphometric Analysis of the Spine and Femur in Ovariectomized Rats Using Micro-Computed Tomographic Scan
por: Shin, Yong-Hwan, et al.
Publicado: (2012)

Association Study of Fibroblast Growth Factor 2 and Fibroblast Growth Factor Receptors Gene Polymorphism in Korean Ossification of the Posterior Longitudinal Ligament Patients
por: Jun, Jae-Kyun, et al.
Publicado: (2012)

Hyperoxia resensitizes chemoresistant human glioblastoma cells to temozolomide
por: Sun, Stella, et al.
Publicado: (2012)

Transsinusoidal Portal Vein Embolization with Ethylene Vinyl Alcohol Copolymer (Onyx): A Feasibility Study in Pigs
por: Smits, Maarten L. J., et al.
Publicado: (2011)

Isthmin inhibits glioma growth through antiangiogenesis in vivo
por: Yuan, Bangqing, et al.
Publicado: (2012)

The Change of Bone Metabolism in Ovariectomized Rats : Analyses of MicroCT Scan and Biochemical Markers of Bone Turnover
por: Yoon, Kyung-Hyuk, et al.
Publicado: (2012)

Increased Vascular Endothelial Growth Factor in the Ventricular Cerebrospinal Fluid as a Predictive Marker for Subsequent Ventriculoperitoneal Shunt Infection : A Comparison Study among Hydrocephalic Patients
por: Lee, Jeong-Hyun, et al.
Publicado: (2012)

Phosphoglycerate dehydrogenase induces glioma cells proliferation and invasion by stabilizing forkhead box M1
por: Liu, Jinlong, et al.
Publicado: (2012)

Rat Peripheral Nerve Regeneration Using Nerve Guidance Channel by Porcine Small Intestinal Submucosa
por: Yi, Jin-Seok, et al.
Publicado: (2013)

Dysregulated Expression Profiles of MicroRNAs of Experimentally Induced Cerebral Aneurysms in Rats
por: Lee, Hyung-Jin, et al.
Publicado: (2013)

The Neuroprotective Effects of Carnosine in Early Stage of Focal Ischemia Rodent Model
por: Park, Hui-Seung, et al.
Publicado: (2014)

Targeting Orthotopic Glioma in Mice with Genetically Engineered Salmonella typhimurium
por: Wen, Min, et al.
Publicado: (2014)

Reliability of Stereotactic Coordinates of 1.5-Tesla and 3-Tesla MRI in Radiosurgery and Functional Neurosurgery
por: Kim, Hae Yu, et al.
Publicado: (2014)

Evaluation of Delcath Systems’ Generation 2 (GEN 2) Melphalan Hemofiltration System in a Porcine Model of Percutaneous Hepatic Perfusion
por: Moeslein, Fred M., et al.
Publicado: (2014)

Matrix Degradative Enzymes and Their Inhibitors during Annular Inflammation: Initial Step of Symptomatic Intervertebral Disc Degeneration
por: Kim, Joo Han, et al.
Publicado: (2014)

Microanatomy and Histological Features of Central Myelin in the Root Exit Zone of Facial Nerve
por: Yee, Gi-Taek, et al.
Publicado: (2014)

The proteomic response in glioblastoma in young patients
por: Deighton, Ruth F., et al.
Publicado: (2014)

Semi-Quantitative Analyses of Hippocampal Heat Shock Protein-70 Expression Based on the Duration of Ischemia and the Volume of Cerebral Infarction in Mice
por: Choi, Jong-Il, et al.
Publicado: (2014)

Curcumin Stimulates Proliferation of Spinal Cord Neural Progenitor Cells via a Mitogen-Activated Protein Kinase Signaling Pathway
por: Son, Sihoon, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_78kogo44k67pk8gf5faofop1k4