Rational design of alcoholic fermentation targeting extracellular carbon

Breeding yeast strains for industrial alcoholic fermentation requires laborious screening due to the lack of in vivo modification strategies. Here we show that quiescence-specific cell wall thickening via synthesis of a major component, 1,3-β-glucan, critically antagonizes cellular fermentation abil...

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Autores principales: Watanabe, Daisuke, Kawashima, Mikiya, Yoshioka, Naoya, Sugimoto, Yukiko, Takagi, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361962/
https://www.ncbi.nlm.nih.gov/pubmed/37479699
http://dx.doi.org/10.1038/s41538-023-00215-0
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author Watanabe, Daisuke
Kawashima, Mikiya
Yoshioka, Naoya
Sugimoto, Yukiko
Takagi, Hiroshi
author_facet Watanabe, Daisuke
Kawashima, Mikiya
Yoshioka, Naoya
Sugimoto, Yukiko
Takagi, Hiroshi
author_sort Watanabe, Daisuke
collection PubMed
description Breeding yeast strains for industrial alcoholic fermentation requires laborious screening due to the lack of in vivo modification strategies. Here we show that quiescence-specific cell wall thickening via synthesis of a major component, 1,3-β-glucan, critically antagonizes cellular fermentation ability by sequestering the available cytoplasmic carbon sources. This study provides insights into glycolytic control and reports an effective and reliable rational fermentation design.
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spelling pubmed-103619622023-07-23 Rational design of alcoholic fermentation targeting extracellular carbon Watanabe, Daisuke Kawashima, Mikiya Yoshioka, Naoya Sugimoto, Yukiko Takagi, Hiroshi NPJ Sci Food Brief Communication Breeding yeast strains for industrial alcoholic fermentation requires laborious screening due to the lack of in vivo modification strategies. Here we show that quiescence-specific cell wall thickening via synthesis of a major component, 1,3-β-glucan, critically antagonizes cellular fermentation ability by sequestering the available cytoplasmic carbon sources. This study provides insights into glycolytic control and reports an effective and reliable rational fermentation design. Nature Publishing Group UK 2023-07-21 /pmc/articles/PMC10361962/ /pubmed/37479699 http://dx.doi.org/10.1038/s41538-023-00215-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Watanabe, Daisuke
Kawashima, Mikiya
Yoshioka, Naoya
Sugimoto, Yukiko
Takagi, Hiroshi
Rational design of alcoholic fermentation targeting extracellular carbon
title Rational design of alcoholic fermentation targeting extracellular carbon
title_full Rational design of alcoholic fermentation targeting extracellular carbon
title_fullStr Rational design of alcoholic fermentation targeting extracellular carbon
title_full_unstemmed Rational design of alcoholic fermentation targeting extracellular carbon
title_short Rational design of alcoholic fermentation targeting extracellular carbon
title_sort rational design of alcoholic fermentation targeting extracellular carbon
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361962/
https://www.ncbi.nlm.nih.gov/pubmed/37479699
http://dx.doi.org/10.1038/s41538-023-00215-0
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