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Representations in human primary visual cortex drift over time

Primary sensory regions are believed to instantiate stable neural representations, yet a number of recent rodent studies suggest instead that representations drift over time. To test whether sensory representations are stable in human visual cortex, we analyzed a large longitudinal dataset of fMRI r...

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Detalles Bibliográficos
Autores principales: Roth, Zvi N., Merriam, Elisha P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361968/
https://www.ncbi.nlm.nih.gov/pubmed/37479723
http://dx.doi.org/10.1038/s41467-023-40144-w
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author Roth, Zvi N.
Merriam, Elisha P.
author_facet Roth, Zvi N.
Merriam, Elisha P.
author_sort Roth, Zvi N.
collection PubMed
description Primary sensory regions are believed to instantiate stable neural representations, yet a number of recent rodent studies suggest instead that representations drift over time. To test whether sensory representations are stable in human visual cortex, we analyzed a large longitudinal dataset of fMRI responses to images of natural scenes. We fit the fMRI responses using an image-computable encoding model and tested how well the model generalized across sessions. We found systematic changes in model fits that exhibited cumulative drift over many months. Convergent analyses pinpoint changes in neural responsivity as the source of the drift, while population-level representational dissimilarities between visual stimuli were unchanged. These observations suggest that downstream cortical areas may read-out a stable representation, even as representations within V1 exhibit drift.
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spelling pubmed-103619682023-07-23 Representations in human primary visual cortex drift over time Roth, Zvi N. Merriam, Elisha P. Nat Commun Article Primary sensory regions are believed to instantiate stable neural representations, yet a number of recent rodent studies suggest instead that representations drift over time. To test whether sensory representations are stable in human visual cortex, we analyzed a large longitudinal dataset of fMRI responses to images of natural scenes. We fit the fMRI responses using an image-computable encoding model and tested how well the model generalized across sessions. We found systematic changes in model fits that exhibited cumulative drift over many months. Convergent analyses pinpoint changes in neural responsivity as the source of the drift, while population-level representational dissimilarities between visual stimuli were unchanged. These observations suggest that downstream cortical areas may read-out a stable representation, even as representations within V1 exhibit drift. Nature Publishing Group UK 2023-07-21 /pmc/articles/PMC10361968/ /pubmed/37479723 http://dx.doi.org/10.1038/s41467-023-40144-w Text en © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Roth, Zvi N.
Merriam, Elisha P.
Representations in human primary visual cortex drift over time
title Representations in human primary visual cortex drift over time
title_full Representations in human primary visual cortex drift over time
title_fullStr Representations in human primary visual cortex drift over time
title_full_unstemmed Representations in human primary visual cortex drift over time
title_short Representations in human primary visual cortex drift over time
title_sort representations in human primary visual cortex drift over time
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361968/
https://www.ncbi.nlm.nih.gov/pubmed/37479723
http://dx.doi.org/10.1038/s41467-023-40144-w
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