Amyloid modifier SERF1a interacts with polyQ-expanded huntingtin-exon 1 via helical interactions and exacerbates polyQ-induced toxicity

Abnormal polyglutamine (polyQ) expansion and fibrillization occur in Huntington’s disease (HD). Amyloid modifier SERF enhances amyloid formation, but the underlying mechanism is not revealed. Here, the fibrillization and toxicity effect of SERF1a on Htt-exon1 are examined. SERF1a enhances the fibril...

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Detalles Bibliográficos
Autores principales: Tsai, Tien-Ying, Chen, Chun-Yu, Lin, Tien-Wei, Lin, Tien-Chang, Chiu, Feng-Lan, Shih, Orion, Chang, Ming-Yun, Lin, Yu-Chun, Su, An-Chung, Chen, Chiung-Mei, Jeng, U-Ser, Kuo, Hung-Chih, Chang, Chi-Fon, Chen, Yun-Ru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361993/
https://www.ncbi.nlm.nih.gov/pubmed/37479809
http://dx.doi.org/10.1038/s42003-023-05142-0

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