Single-cell chromatin accessibility profiling of acute myeloid leukemia reveals heterogeneous lineage composition upon therapy-resistance

Acute myeloid leukemia (AML) is a heterogeneous disease characterized by high rate of therapy resistance. Since the cell of origin can impact response to therapy, it is crucial to understand the lineage composition of AML cells at time of therapy resistance. Here we leverage single-cell chromatin ac...

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Detalles Bibliográficos
Autores principales: Fan, Huihui, Wang, Feng, Zeng, Andy, Murison, Alex, Tomczak, Katarzyna, Hao, Dapeng, Jelloul, Fatima Zahra, Wang, Bofei, Barrodia, Praveen, Liang, Shaoheng, Chen, Ken, Wang, Linghua, Zhao, Zhongming, Rai, Kunal, Jain, Abhinav K., Dick, John, Daver, Naval, Futreal, Andy, Abbas, Hussein A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362028/
https://www.ncbi.nlm.nih.gov/pubmed/37479893
http://dx.doi.org/10.1038/s42003-023-05120-6

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