p53 restoration in small cell lung cancer identifies a latent cyclophilin-dependent necrosis mechanism

The p53 tumor suppressor regulates multiple context-dependent tumor suppressive programs. Although p53 is mutated in ~90% of small cell lung cancer (SCLC) tumors, how p53 mediates tumor suppression in this context is unknown. Here, using a mouse model of SCLC in which endogenous p53 expression can b...

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Detalles Bibliográficos
Autores principales: Acosta, Jonuelle, Li, Qinglan, Freeburg, Nelson F., Murali, Nivitha, Indeglia, Alexandra, Grothusen, Grant P., Cicchini, Michelle, Mai, Hung, Gladstein, Amy C., Adler, Keren M., Doerig, Katherine R., Li, Jinyang, Ruiz-Torres, Miguel, Manning, Kimberly L., Stanger, Ben Z., Busino, Luca, Murphy, Maureen, Wan, Liling, Feldser, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362054/
https://www.ncbi.nlm.nih.gov/pubmed/37479684
http://dx.doi.org/10.1038/s41467-023-40161-9

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