Cargando…

Single-cell sequencing reveals the landscape of the human brain metastatic microenvironment

Brain metastases is the most common intracranial tumor and account for approximately 20% of all systematic cancer cases. It is a leading cause of death in advanced-stage cancer, resulting in a five-year overall survival rate below 10%. Therefore, there is a critical need to identify effective biomar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Qianqian, Ruiz, Jimmy, Xing, Fei, Lo, Hui-Wen, Craddock, Lou, Pullikuth, Ashok K., Miller, Lance D., Soike, Michael H., O’Neill, Stacey S., Watabe, Kounosuke, Chan, Michael D., Su, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362065/ https://www.ncbi.nlm.nih.gov/pubmed/37479733 http://dx.doi.org/10.1038/s42003-023-05124-2

Ejemplares similares

CD138 plasma cells may predict brain metastasis recurrence following resection and stereotactic radiosurgery
por: Soike, Michael H., et al.
Publicado: (2019)

Multi-Omics Analysis of Brain Metastasis Outcomes Following Craniotomy
por: Su, Jing, et al.
Publicado: (2021)

Dissecting intratumoral myeloid cell plasticity by single cell RNA‐seq
por: Song, Qianqian, et al.
Publicado: (2019)

Identification of CD37, cystatin A, and IL-23A gene expression in association with brain metastasis: analysis of a prospective trial
por: Dohm, Ammoren, et al.
Publicado: (2019)

Bulk and Single-Cell Profiling of Breast Tumors Identifies TREM-1 as a Dominant Immune Suppressive Marker Associated With Poor Outcomes
por: Pullikuth, Ashok K., et al.
Publicado: (2021)

Collagen deposition within brain metastases is associated with leptomeningeal failure after  cavity-directed radiosurgery
por: Abdulhaleem, Mohammed, et al.
Publicado: (2023)

Systems biology approach to studying proliferation-dependent prognostic subnetworks in breast cancer
por: Song, Qianqian, et al.
Publicado: (2015)

Conservation of immune gene signatures in solid tumors and prognostic implications
por: Chifman, Julia, et al.
Publicado: (2016)

TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment
por: Sirkisoon, Sherona R., et al.
Publicado: (2019)

BSCI-13. TUMOR-SPECIFIC tGLI1 TRANSCRIPTION FACTOR MEDIATES BREAST CANCER BRAIN METASTASIS VIA ACTIVATING METASTASIS-INITIATING CANCER STEM CELLS AND ASTROCYTES IN THE TUMOR MICROENVIRONMENT
por: Sirkisoon, Sherona, et al.
Publicado: (2019)

Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung
por: Tyagi, Abhishek, et al.
Publicado: (2021)

Evolution of Mutational Landscape and Tumor Immune-Microenvironment in Liver Oligo-Metastatic Colorectal Cancer
por: Ottaiano, Alessandro, et al.
Publicado: (2020)

Prosaposin down-modulation decreases metastatic prostate cancer cell adhesion, migration, and invasion
por: Hu, Siyi, et al.
Publicado: (2010)

Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition
por: Espinoza, Ingrid, et al.
Publicado: (2013)

Immunosuppressive Microenvironment Revealed by Immune Cell Landscape in Pre-metastatic Liver of Colorectal Cancer
por: Zeng, Dongqiang, et al.
Publicado: (2021)

Impact of chemotherapeutic agents on liver microenvironment: oxaliplatin create a pro-metastatic landscape
por: Ma, Yuanyuan, et al.
Publicado: (2023)

Use of comprehensive genomic profiling for biomarker discovery for the management of non-small cell lung cancer brain metastases
por: Abdulhaleem, Mohammed, et al.
Publicado: (2023)

The Confounders of Cancer Immunotherapy: Roles of Lifestyle, Metabolic Disorders and Sociological Factors
por: Deshpande, Ravindra Pramod, et al.
Publicado: (2020)

Metabolism in the progression and metastasis of brain tumors
por: Tyagi, Abhishek, et al.
Publicado: (2022)

The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis
por: Carpenter, Richard L., et al.
Publicado: (2015)

Biochemical and Anti-Triple Negative Metastatic Breast Tumor Cell Properties of Psammaplins
por: Zhou, Yu-Dong, et al.
Publicado: (2018)

Survival and Failure Outcomes Predicted by Brain Metastasis Volumetric Kinetics in Melanoma Patients Following Upfront Treatment with Stereotactic Radiosurgery Alone
por: LeCompte, Michael C, et al.
Publicado: (2017)

Exosomal miR-4466 from nicotine-activated neutrophils promotes tumor cell stemness and metabolism in lung cancer metastasis
por: Tyagi, Abhishek, et al.
Publicado: (2022)

Comprehensive and Computable Molecular Diagnostic Panel (C2Dx) From Small Volume Specimens for Precision Oncology: Molecular Subtyping of Non-Small Cell Lung Cancer From Fine Needle Aspirates
por: Su, Jing, et al.
Publicado: (2021)

Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain
por: Xing, Fei, et al.
Publicado: (2013)

4026 Dissecting the role of microenvironment heterogeneity on metastatic tumor cell phenotype at an engineered metastatic niche
por: Orbach, Sophia, et al.
Publicado: (2020)

Metastatic melanoma in an esophagus demonstrating Barrett esophagus with high grade dysplasia
por: Trembath, Dimitri G, et al.
Publicado: (2013)

Trypanosomatid RACK1 Orthologs Show Functional Differences Associated with Translation Despite Similar Roles in Leishmania Pathogenesis
por: Choudhury, Kohelia, et al.
Publicado: (2011)

Single-cell RNA landscape of the osteoimmunology microenvironment in periodontitis
por: Chen, Yue, et al.
Publicado: (2022)

Addressing the Adult Soft Tissue Sarcoma Microenvironment with Intratumoral Immunotherapy
por: Raj, Shailaja, et al.
Publicado: (2018)

Visualizing movement in the tumor microenvironment landscape
por: Calvo, Veronica, et al.
Publicado: (2013)

Nicotine promotes brain metastasis by polarizing microglia and suppressing innate immune function
por: Wu, Shih-Ying, et al.
Publicado: (2020)

Transcriptomic Features of T Cell-Barren Tumors Are Conserved Across Diverse Tumor Types
por: Routh, Eric D., et al.
Publicado: (2020)

Immune gene signatures and tumor intrinsic markers delineate novel immunogenic subtypes of breast cancer
por: Miller, Lance D, et al.
Publicado: (2014)

Exosome-mediated transfer of miR-10b promotes cell invasion in breast cancer
por: Singh, Ramesh, et al.
Publicado: (2014)

The genomic and transcriptomic landscapes of clock genes reveal the significance of circadian rhythm in the progression and immune microenvironment of metastatic colorectal cancer
por: Zhang, Long, et al.
Publicado: (2022)

The updated landscape of tumor microenvironment and drug repurposing
por: Jin, Ming-Zhu, et al.
Publicado: (2020)

Single-cell sequencing reveals the immune microenvironment landscape related to anti-PD-1 resistance in metastatic colorectal cancer with high microsatellite instability
por: Wu, Tao, et al.
Publicado: (2023)

Cardiac Involvement by Human Herpesvirus 8-Positive Diffuse Large B-Cell Lymphoma: An Unusual Presentation in a Patient with Human Immunodeficiency Virus
por: Fenu, Elena M., et al.
Publicado: (2022)

Tumor Microenvironment Immunosuppression: A Roadblock to CAR T-Cell Advancement in Solid Tumors
por: Johnson, Abigail, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_jr9hjpqjl7f0g3f9dooa7foj4m