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Maternal sodium acetate supplementation promotes lactation performance of sows and their offspring growth performance
Milk yield and composition are critical determining factors for the early growth and development of neonates. The objective of this experiment was to comprehensively evaluate the effects of dietary sodium acetate (SA) supplementation on the milk yield and composition of sows and the growth performan...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362078/ https://www.ncbi.nlm.nih.gov/pubmed/37484994 http://dx.doi.org/10.1016/j.aninu.2023.04.003 |
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author | Qi, Yingao Zheng, Tenghui Yang, Siwang Zhang, Qianzi Li, Baofeng Zeng, Xiangfang Zhong, Yongxing Chen, Fang Guan, Wutai Zhang, Shihai |
author_facet | Qi, Yingao Zheng, Tenghui Yang, Siwang Zhang, Qianzi Li, Baofeng Zeng, Xiangfang Zhong, Yongxing Chen, Fang Guan, Wutai Zhang, Shihai |
author_sort | Qi, Yingao |
collection | PubMed |
description | Milk yield and composition are critical determining factors for the early growth and development of neonates. The objective of this experiment was to comprehensively evaluate the effects of dietary sodium acetate (SA) supplementation on the milk yield and composition of sows and the growth performance of their offspring. A total of 80 sows (Landrace × Yorkshire, 3 to 6 parity) were randomly assigned to 2 groups (with or without 0.1% SA) from d 85 of gestation to d 21 of lactation. The result shows that maternal 0.1% SA supplementation significantly increased sows milk yield, milk fat, immunoglobulin A (IgA) and IgG content in milk (P < 0.05), with the up-regulation of short-chain fatty acids receptors (GPR41 and GPR43) expression and the activation of mammalian target of rapamycin complex C1 (mTORC1) signaling pathway. Consistently, in our in vitro experiment, SA also activated mTORC1 signaling in porcine mammary epithelial cells (P < 0.05). Furthermore, the improvement of milk quality and quantity caused by maternal SA supplementation led to the increase in body weight (BW) and average daily weight gain (ADG) of weaning piglets, with the improvement of gut health and colonization of the beneficial bacteria (P < 0.05). In conclusion, maternal supplementation of 0.1% SA improved the lactation performance (milk yield and milk fat) of sows, possibly with the activation of GPR41/GPR43-mTORC1 signaling. Furthermore, enhanced milk quality improved growth performance, gut health and the colonization of beneficial microbial flora of their piglets. |
format | Online Article Text |
id | pubmed-10362078 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-103620782023-07-23 Maternal sodium acetate supplementation promotes lactation performance of sows and their offspring growth performance Qi, Yingao Zheng, Tenghui Yang, Siwang Zhang, Qianzi Li, Baofeng Zeng, Xiangfang Zhong, Yongxing Chen, Fang Guan, Wutai Zhang, Shihai Anim Nutr Original Research Article Milk yield and composition are critical determining factors for the early growth and development of neonates. The objective of this experiment was to comprehensively evaluate the effects of dietary sodium acetate (SA) supplementation on the milk yield and composition of sows and the growth performance of their offspring. A total of 80 sows (Landrace × Yorkshire, 3 to 6 parity) were randomly assigned to 2 groups (with or without 0.1% SA) from d 85 of gestation to d 21 of lactation. The result shows that maternal 0.1% SA supplementation significantly increased sows milk yield, milk fat, immunoglobulin A (IgA) and IgG content in milk (P < 0.05), with the up-regulation of short-chain fatty acids receptors (GPR41 and GPR43) expression and the activation of mammalian target of rapamycin complex C1 (mTORC1) signaling pathway. Consistently, in our in vitro experiment, SA also activated mTORC1 signaling in porcine mammary epithelial cells (P < 0.05). Furthermore, the improvement of milk quality and quantity caused by maternal SA supplementation led to the increase in body weight (BW) and average daily weight gain (ADG) of weaning piglets, with the improvement of gut health and colonization of the beneficial bacteria (P < 0.05). In conclusion, maternal supplementation of 0.1% SA improved the lactation performance (milk yield and milk fat) of sows, possibly with the activation of GPR41/GPR43-mTORC1 signaling. Furthermore, enhanced milk quality improved growth performance, gut health and the colonization of beneficial microbial flora of their piglets. KeAi Publishing 2023-04-25 /pmc/articles/PMC10362078/ /pubmed/37484994 http://dx.doi.org/10.1016/j.aninu.2023.04.003 Text en © 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Research Article Qi, Yingao Zheng, Tenghui Yang, Siwang Zhang, Qianzi Li, Baofeng Zeng, Xiangfang Zhong, Yongxing Chen, Fang Guan, Wutai Zhang, Shihai Maternal sodium acetate supplementation promotes lactation performance of sows and their offspring growth performance |
title | Maternal sodium acetate supplementation promotes lactation performance of sows and their offspring growth performance |
title_full | Maternal sodium acetate supplementation promotes lactation performance of sows and their offspring growth performance |
title_fullStr | Maternal sodium acetate supplementation promotes lactation performance of sows and their offspring growth performance |
title_full_unstemmed | Maternal sodium acetate supplementation promotes lactation performance of sows and their offspring growth performance |
title_short | Maternal sodium acetate supplementation promotes lactation performance of sows and their offspring growth performance |
title_sort | maternal sodium acetate supplementation promotes lactation performance of sows and their offspring growth performance |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362078/ https://www.ncbi.nlm.nih.gov/pubmed/37484994 http://dx.doi.org/10.1016/j.aninu.2023.04.003 |
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