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3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities
Repairing significant bone defects remains a critical challenge, raising the clinical demand to design novel bone biomaterials that incorporate osteogenic and angiogenic properties to support the regeneration of vascularized bone. Bioactive glass scaffolds can stimulate angiogenesis and osteogenesis...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362084/ https://www.ncbi.nlm.nih.gov/pubmed/37483767 http://dx.doi.org/10.1016/j.heliyon.2023.e17050 |
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author | Aldhaher, Abdullah Shahabipour, Fahimeh Shaito, Abdullah Al-Assaf, Saphwan Elnour, Ahmed A.M. Sallam, El Bashier Teimourtash, Shahin Elfadil, Abdelgadir A. |
author_facet | Aldhaher, Abdullah Shahabipour, Fahimeh Shaito, Abdullah Al-Assaf, Saphwan Elnour, Ahmed A.M. Sallam, El Bashier Teimourtash, Shahin Elfadil, Abdelgadir A. |
author_sort | Aldhaher, Abdullah |
collection | PubMed |
description | Repairing significant bone defects remains a critical challenge, raising the clinical demand to design novel bone biomaterials that incorporate osteogenic and angiogenic properties to support the regeneration of vascularized bone. Bioactive glass scaffolds can stimulate angiogenesis and osteogenesis. In addition, natural or synthetic polymers exhibit structural similarity with extracellular matrix (ECM) components and have superior biocompatibility and biodegradability. Thus, there is a need to prepare composite scaffolds of hydrogels for vascularized bone, which incorporate to improve the mechanical properties and bioactivity of natural polymers. In addition, those composites' 3-dimensional (3D) form offer regenerative benefits such as direct doping of the scaffold with ions. This review presents a comprehensive discussion of composite scaffolds incorporated with BaG, focusing on their effects on osteo-inductivity and angiogenic properties. Moreover, the adaptation of the ion-doped hydrogel composite scaffold into a 3D scaffold for the generation of vascularized bone tissue is exposed. Finally, we highlight the challenges and future of manufacturing such biomaterials. |
format | Online Article Text |
id | pubmed-10362084 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-103620842023-07-23 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities Aldhaher, Abdullah Shahabipour, Fahimeh Shaito, Abdullah Al-Assaf, Saphwan Elnour, Ahmed A.M. Sallam, El Bashier Teimourtash, Shahin Elfadil, Abdelgadir A. Heliyon Review Article Repairing significant bone defects remains a critical challenge, raising the clinical demand to design novel bone biomaterials that incorporate osteogenic and angiogenic properties to support the regeneration of vascularized bone. Bioactive glass scaffolds can stimulate angiogenesis and osteogenesis. In addition, natural or synthetic polymers exhibit structural similarity with extracellular matrix (ECM) components and have superior biocompatibility and biodegradability. Thus, there is a need to prepare composite scaffolds of hydrogels for vascularized bone, which incorporate to improve the mechanical properties and bioactivity of natural polymers. In addition, those composites' 3-dimensional (3D) form offer regenerative benefits such as direct doping of the scaffold with ions. This review presents a comprehensive discussion of composite scaffolds incorporated with BaG, focusing on their effects on osteo-inductivity and angiogenic properties. Moreover, the adaptation of the ion-doped hydrogel composite scaffold into a 3D scaffold for the generation of vascularized bone tissue is exposed. Finally, we highlight the challenges and future of manufacturing such biomaterials. Elsevier 2023-07-05 /pmc/articles/PMC10362084/ /pubmed/37483767 http://dx.doi.org/10.1016/j.heliyon.2023.e17050 Text en © 2023 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Aldhaher, Abdullah Shahabipour, Fahimeh Shaito, Abdullah Al-Assaf, Saphwan Elnour, Ahmed A.M. Sallam, El Bashier Teimourtash, Shahin Elfadil, Abdelgadir A. 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities |
title | 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities |
title_full | 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities |
title_fullStr | 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities |
title_full_unstemmed | 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities |
title_short | 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities |
title_sort | 3d hydrogel/ bioactive glass scaffolds in bone tissue engineering: status and future opportunities |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362084/ https://www.ncbi.nlm.nih.gov/pubmed/37483767 http://dx.doi.org/10.1016/j.heliyon.2023.e17050 |
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