Tongue necrosis as a manifestation of immune dysfunction: A complex case of systemic lupus erythematosus, histoplasmosis, and macrophage activation syndrome

Immune dysfunction can manifest in unexpected ways. We present the case of a patient with systemic lupus erythematosus (SLE) in whom the first sign of disseminated histoplasmosis and consequent macrophage activation syndrome (MAS) was tongue necrosis. In those with immune dysfunction, a high index o...

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Autores principales: Walsh, Madalyn, Feng, Alick, Lenert, Petar, Kumar, Bharat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362117/
https://www.ncbi.nlm.nih.gov/pubmed/37484751
http://dx.doi.org/10.1002/ccr3.7735
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author Walsh, Madalyn
Feng, Alick
Lenert, Petar
Kumar, Bharat
author_facet Walsh, Madalyn
Feng, Alick
Lenert, Petar
Kumar, Bharat
author_sort Walsh, Madalyn
collection PubMed
description Immune dysfunction can manifest in unexpected ways. We present the case of a patient with systemic lupus erythematosus (SLE) in whom the first sign of disseminated histoplasmosis and consequent macrophage activation syndrome (MAS) was tongue necrosis. In those with immune dysfunction, a high index of clinical suspicion for atypical infections is warranted.
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spelling pubmed-103621172023-07-23 Tongue necrosis as a manifestation of immune dysfunction: A complex case of systemic lupus erythematosus, histoplasmosis, and macrophage activation syndrome Walsh, Madalyn Feng, Alick Lenert, Petar Kumar, Bharat Clin Case Rep Case Report Immune dysfunction can manifest in unexpected ways. We present the case of a patient with systemic lupus erythematosus (SLE) in whom the first sign of disseminated histoplasmosis and consequent macrophage activation syndrome (MAS) was tongue necrosis. In those with immune dysfunction, a high index of clinical suspicion for atypical infections is warranted. John Wiley and Sons Inc. 2023-07-21 /pmc/articles/PMC10362117/ /pubmed/37484751 http://dx.doi.org/10.1002/ccr3.7735 Text en © 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Walsh, Madalyn
Feng, Alick
Lenert, Petar
Kumar, Bharat
Tongue necrosis as a manifestation of immune dysfunction: A complex case of systemic lupus erythematosus, histoplasmosis, and macrophage activation syndrome
title Tongue necrosis as a manifestation of immune dysfunction: A complex case of systemic lupus erythematosus, histoplasmosis, and macrophage activation syndrome
title_full Tongue necrosis as a manifestation of immune dysfunction: A complex case of systemic lupus erythematosus, histoplasmosis, and macrophage activation syndrome
title_fullStr Tongue necrosis as a manifestation of immune dysfunction: A complex case of systemic lupus erythematosus, histoplasmosis, and macrophage activation syndrome
title_full_unstemmed Tongue necrosis as a manifestation of immune dysfunction: A complex case of systemic lupus erythematosus, histoplasmosis, and macrophage activation syndrome
title_short Tongue necrosis as a manifestation of immune dysfunction: A complex case of systemic lupus erythematosus, histoplasmosis, and macrophage activation syndrome
title_sort tongue necrosis as a manifestation of immune dysfunction: a complex case of systemic lupus erythematosus, histoplasmosis, and macrophage activation syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362117/
https://www.ncbi.nlm.nih.gov/pubmed/37484751
http://dx.doi.org/10.1002/ccr3.7735
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AT lenertpetar tonguenecrosisasamanifestationofimmunedysfunctionacomplexcaseofsystemiclupuserythematosushistoplasmosisandmacrophageactivationsyndrome
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