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Metformin restores cognitive dysfunction and histopathological deficits in an animal model of sporadic Alzheimer's disease

BACKGROUND: Metformin has been introduced as a neuroprotective agent in recent years. Here we evaluate the therapeutic effects of metformin in sporadic mouse model of Alzheimer's disease (SAD). METHODS: AD was induced by streptozotocin (STZ, 0.5 mg/kg) on days 1 and 3. Metformin (MET, 200 mg/kg...

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Detalles Bibliográficos
Autores principales:	Rabieipoor, Saghar, Zare, Meysam, Ettcheto, Miren, Camins, Antoni, Javan, Mohammad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362193/ https://www.ncbi.nlm.nih.gov/pubmed/37483818 http://dx.doi.org/10.1016/j.heliyon.2023.e17873

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