Cargando…

Targeting the deacetylase SIRT6 unveils spliceosome deregulation as exploitable vulnerability for aggressive myeloma

Detalles Bibliográficos
Autores principales:	Gelli, Elisa, Soncini, Debora, Becherini, Pamela, Martinuzzi, Claudia, Todoerti, Katia, Cagnetta, Antonia, Aquino, Sara, Guolo, Fabio, Miglino, Maurizio, Bruzzone, Santina, Nencioni, Alessio, Neri, Antonino, Lemoli, Roberto M., Cea, Michele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society of Hematology 2023
Materias:	Research Letter
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362259/ https://www.ncbi.nlm.nih.gov/pubmed/36897214 http://dx.doi.org/10.1182/bloodadvances.2022009035

Ejemplares similares

CD38-Induced Metabolic Dysfunction Primes Multiple Myeloma Cells for NAD(+)-Lowering Agents
por: Becherini, Pamela, et al.
Publicado: (2023)

Apoptosis reprogramming triggered by splicing inhibitors sensitizes multiple myeloma cells to Venetoclax treatment
por: Soncini, Debora, et al.
Publicado: (2021)

Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells’ vulnerability to DNA-damaging agents
por: Cagnetta, Antonia, et al.
Publicado: (2018)

The new small tyrosine kinase inhibitor ARQ531 targets acute myeloid leukemia cells by disrupting multiple tumor-addicted programs
por: Soncini, Debora, et al.
Publicado: (2019)

P530: CPX-351 INDUCTION IS ABLE TO INDUCE MRD NEGATIVE CR IN A SIGNIFICATIVE PROPORTION OF VERY HIGH RISK AML PATIENTS, REGARDLESS OF MUTATIONAL BURDEN, ALLOWING FOR BRIDGING TO TRANSPLANTATION
por: Riva, Carola, et al.
Publicado: (2023)

Mechanisms and Clinical Applications of Genome Instability in Multiple Myeloma
por: Cagnetta, Antonia, et al.
Publicado: (2015)

P381: FULL PEDIATRIC INDUCTION IN ADULTS AGED UP TO 55 YEARS WITH PHILADELPHIA-NEGATIVE ACUTE LYMPHOBLASTIC LEUKEMIA IS WELL TOLERATED AND RESULTS IN VERY HIGH CURE RATE
por: Maio, Elena, et al.
Publicado: (2023)

PB1742: FEASIBILITY AND EFFICACY OF A PEG-ASPARAGINASE-BASED TREATMENT PROTOCOL IN ELDERLY PHILADELPHIA-NEGATIVE ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS
por: Vernarecci, Chiara, et al.
Publicado: (2023)

Synergistic Interactions between HDAC and Sirtuin Inhibitors in Human Leukemia Cells
por: Cea, Michele, et al.
Publicado: (2011)

Deregulation of secondary metabolism in a histone deacetylase mutant of Penicillium chrysogenum
por: Guzman‐Chavez, Fernando, et al.
Publicado: (2018)

Somatic Mutations in Core Spliceosome Components Promote Tumorigenesis and Generate an Exploitable Vulnerability in Human Cancer
por: Sette, Claudio, et al.
Publicado: (2022)

SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice
por: Becherini, Pamela, et al.
Publicado: (2021)

Daratumumab in the treatment of C3 glomerulopathy with monoclonal gammopathy: a case report and literature review
por: Esposito, Pasquale, et al.
Publicado: (2023)

Catastrophic NAD(+) Depletion in Activated T Lymphocytes through Nampt Inhibition Reduces Demyelination and Disability in EAE
por: Bruzzone, Santina, et al.
Publicado: (2009)

Spliceosome Database: a tool for tracking components of the spliceosome
por: Cvitkovic, Ivan, et al.
Publicado: (2013)

Histone deacetylase 8 is deregulated in urothelial cancer but not a target for efficient treatment
por: Lehmann, Maria, et al.
Publicado: (2014)

Iminosugar-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Potential Anti-Pancreatic Cancer Agents
por: Conforti, Irene, et al.
Publicado: (2023)

Structures of the human pre-catalytic spliceosome and its precursor spliceosome
por: Zhan, Xiechao, et al.
Publicado: (2018)

Human spliceosomal snRNA sequence variants generate variant spliceosomes
por: Mabin, Justin W., et al.
Publicado: (2021)

Spliceosome assembly and regulation: insights from analysis of highly reduced spliceosomes
por: Black, Corbin S., et al.
Publicado: (2023)

Concordance of deregulated mechanisms unveiled in underpowered experiments: PTBP1 knockdown case study
por: Gardeux, Vincent, et al.
Publicado: (2014)

S217: POST-TRANSPLANT NIVOLUMAB PLUS UNSELECTED AUTOLOGOUS LYMPHOCYTES IN REFRACTORY HODGKIN LYMPHOMA RESULTS IN VERY HIGH REMISSION RATE AND EXCELLENT SURVIVAL AND IT IS ASSOCIATED WITH NK CELL EXPANSION
por: Guolo, Fabio, et al.
Publicado: (2023)

Expression levels of NONO, a nuclear protein primarily involved in paraspeckles function, are associated with several deregulated molecular pathways and poor clinical outcome in multiple myeloma
por: Ronchetti, Domenica, et al.
Publicado: (2022)

Challenging the spliceosome machine
por: Weir, Michael, et al.
Publicado: (2006)

Structure of spliceosomal ribonucleoproteins
por: Krummel, Daniel Aaron Pomeranz, et al.
Publicado: (2010)

CryoEM structures of two spliceosomal complexes: starter and dessert at the spliceosome feast
por: Nguyen, Thi Hoang Duong, et al.
Publicado: (2016)

Differential Transcriptome Profiling Unveils Novel Deregulated Gene Signatures Involved in Pathogenesis of Alzheimer’s Disease
por: Singh, Himanshu Narayan, et al.
Publicado: (2022)

Grb7 Upregulation Is a Molecular Adaptation to HER2 Signaling Inhibition Due to Removal of Akt-Mediated Gene Repression
por: Nencioni, Alessio, et al.
Publicado: (2010)

Sirtuin 6 Regulates the Activation of the ATP/Purinergic Axis in Endothelial Cells
por: Astigiano, Cecilia, et al.
Publicado: (2023)

Patterns of conservation of spliceosomal intron structures and spliceosome divergence in representatives of the diplomonad and parabasalid lineages
por: Hudson, Andrew J., et al.
Publicado: (2019)

Rejuvenating Sirtuins: The Rise of a New Family of Cancer Drug Targets
por: Bruzzone, Santina, et al.
Publicado: (2013)

Fludarabine, High-Dose Cytarabine and Idarubicin-Based Induction May Overcome the Negative Prognostic Impact of FLT3-ITD in NPM1 Mutated AML, Irrespectively of FLT3-ITD Allelic Burden
por: Minetto, Paola, et al.
Publicado: (2020)

The spliceosome as target for anticancer treatment
por: van Alphen, R J, et al.
Publicado: (2009)

Origin and evolution of spliceosomal introns
por: Rogozin, Igor B, et al.
Publicado: (2012)

Spliceosome Mutations in Uveal Melanoma
por: Nguyen, Josephine Q.N., et al.
Publicado: (2020)

Spliceosomal snRNA Epitranscriptomics
por: Morais, Pedro, et al.
Publicado: (2021)

The impact of spliceosome mutations in MDS
por: Boultwood, Jacqueline, et al.
Publicado: (2019)

Phosphoprotein network analysis of white adipose tissues unveils deregulated pathways in response to high-fat diet
por: Asfa, Alli Shaik, et al.
Publicado: (2016)

Combined use of protein biomarkers and network analysis unveils deregulated regulatory circuits in Duchenne muscular dystrophy
por: Parolo, Silvia, et al.
Publicado: (2018)

Deregulated FASN Expression in BRAF Inhibitor-Resistant Melanoma Cells Unveils New Targets for Drug Combinations
por: Stamatakos, Serena, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_rbjdo9piqqqui0g58nlokp0gmr