A small non-interface surface epitope in human IL18 mediates the dynamics and self-assembly of IL18-IL18BP heterodimers

Interleukin 18 (IL18) is a pro-inflammatory cytokine that modulates innate and adaptive immune responses. IL18 activity is tightly controlled by the constitutively secreted IL18 binding protein (IL18BP). PDB structures of human IL18 showed that a short stretch of amino acids between 68 and 81 adopte...

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Detalles Bibliográficos
Autores principales: Yazıcı, Yılmaz Yücehan, Belkaya, Serkan, Timucin, Emel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362265/
https://www.ncbi.nlm.nih.gov/pubmed/37484491
http://dx.doi.org/10.1016/j.csbj.2023.06.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362265/
https://www.ncbi.nlm.nih.gov/pubmed/37484491
http://dx.doi.org/10.1016/j.csbj.2023.06.021

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