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Donor perspectives on informed consent and use of biospecimens for brain organoid research
Debates about the ethics of human brain organoids have proceeded without the input of individuals whose brains are being modeled. Interviews with donors of biospecimens for brain organoid research revealed overall enthusiasm for brain organoids as a tool for biomedical discovery, alongside a desire...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362497/ https://www.ncbi.nlm.nih.gov/pubmed/37352851 http://dx.doi.org/10.1016/j.stemcr.2023.05.019 |
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author | MacDuffie, Katherine E. Stein, Jason L. Doherty, Dan Jayadev, Suman Girault, Jessica B. Emmons, Katherine A. Glass, Madison Rose Dempsey, Jennifer C. Marrus, Natasha Botteron, Kelly N. Dager, Stephen R. Estes, Annette M. Piven, Joseph Wilfond, Benjamin S. |
author_facet | MacDuffie, Katherine E. Stein, Jason L. Doherty, Dan Jayadev, Suman Girault, Jessica B. Emmons, Katherine A. Glass, Madison Rose Dempsey, Jennifer C. Marrus, Natasha Botteron, Kelly N. Dager, Stephen R. Estes, Annette M. Piven, Joseph Wilfond, Benjamin S. |
author_sort | MacDuffie, Katherine E. |
collection | PubMed |
description | Debates about the ethics of human brain organoids have proceeded without the input of individuals whose brains are being modeled. Interviews with donors of biospecimens for brain organoid research revealed overall enthusiasm for brain organoids as a tool for biomedical discovery, alongside a desire for ongoing engagement with research teams to learn the results of the research, to allow transfer of decision-making authority over time, and to ensure ethical boundaries are not crossed. Future work is needed to determine the most feasible and resource-efficient way to longitudinally engage donors participating in brain organoid research. |
format | Online Article Text |
id | pubmed-10362497 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-103624972023-07-23 Donor perspectives on informed consent and use of biospecimens for brain organoid research MacDuffie, Katherine E. Stein, Jason L. Doherty, Dan Jayadev, Suman Girault, Jessica B. Emmons, Katherine A. Glass, Madison Rose Dempsey, Jennifer C. Marrus, Natasha Botteron, Kelly N. Dager, Stephen R. Estes, Annette M. Piven, Joseph Wilfond, Benjamin S. Stem Cell Reports Forum Debates about the ethics of human brain organoids have proceeded without the input of individuals whose brains are being modeled. Interviews with donors of biospecimens for brain organoid research revealed overall enthusiasm for brain organoids as a tool for biomedical discovery, alongside a desire for ongoing engagement with research teams to learn the results of the research, to allow transfer of decision-making authority over time, and to ensure ethical boundaries are not crossed. Future work is needed to determine the most feasible and resource-efficient way to longitudinally engage donors participating in brain organoid research. Elsevier 2023-06-22 /pmc/articles/PMC10362497/ /pubmed/37352851 http://dx.doi.org/10.1016/j.stemcr.2023.05.019 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Forum MacDuffie, Katherine E. Stein, Jason L. Doherty, Dan Jayadev, Suman Girault, Jessica B. Emmons, Katherine A. Glass, Madison Rose Dempsey, Jennifer C. Marrus, Natasha Botteron, Kelly N. Dager, Stephen R. Estes, Annette M. Piven, Joseph Wilfond, Benjamin S. Donor perspectives on informed consent and use of biospecimens for brain organoid research |
title | Donor perspectives on informed consent and use of biospecimens for brain organoid research |
title_full | Donor perspectives on informed consent and use of biospecimens for brain organoid research |
title_fullStr | Donor perspectives on informed consent and use of biospecimens for brain organoid research |
title_full_unstemmed | Donor perspectives on informed consent and use of biospecimens for brain organoid research |
title_short | Donor perspectives on informed consent and use of biospecimens for brain organoid research |
title_sort | donor perspectives on informed consent and use of biospecimens for brain organoid research |
topic | Forum |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362497/ https://www.ncbi.nlm.nih.gov/pubmed/37352851 http://dx.doi.org/10.1016/j.stemcr.2023.05.019 |
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