Familial Alzheimer’s disease-associated PSEN1 mutations affect neurodevelopment through increased Notch signaling

Alzheimer’s disease (AD) is the most common neurodegenerative disorder, but its root cause may lie in neurodevelopment. PSEN1 mutations cause the majority of familial AD, potentially by disrupting proper Notch signaling, causing early unnoticed cellular changes that affect later AD progression. Whil...

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Detalles Bibliográficos
Autores principales: Hurley, Erin M., Mozolewski, Pawel, Dobrowolski, Radek, Hsieh, Jenny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362499/
https://www.ncbi.nlm.nih.gov/pubmed/37352850
http://dx.doi.org/10.1016/j.stemcr.2023.05.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362499/
https://www.ncbi.nlm.nih.gov/pubmed/37352850
http://dx.doi.org/10.1016/j.stemcr.2023.05.018

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