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Familial Alzheimer’s disease-associated PSEN1 mutations affect neurodevelopment through increased Notch signaling
Alzheimer’s disease (AD) is the most common neurodegenerative disorder, but its root cause may lie in neurodevelopment. PSEN1 mutations cause the majority of familial AD, potentially by disrupting proper Notch signaling, causing early unnoticed cellular changes that affect later AD progression. Whil...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362499/ https://www.ncbi.nlm.nih.gov/pubmed/37352850 http://dx.doi.org/10.1016/j.stemcr.2023.05.018 |