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Global burden and drivers of hyperglycemia: Estimates and predictions from 1990 to 2050
Hyperglycemia is a key risk factor for death and disability worldwide. To better inform prevention strategies, we aimed to delineate and predict the temporal, spatial, and demographic patterns in mean fasting plasma glucose (FPG) levels and their related disease burden globally. Based on the Global...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362522/ https://www.ncbi.nlm.nih.gov/pubmed/37485083 http://dx.doi.org/10.1016/j.xinn.2023.100450 |
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author | Qiu, Hui-Ling Fan, Shujun Zhou, Kaixin He, Zhini Browning, Matthew H.E.M. Knibbs, Luke D. Zhao, Tianyu Luo, Ya-Na Liu, Xiao-Xuan Hu, Li-Xin Li, Jia-Xin Zhang, Yi-Dan Xie, Yu-Ting Heinrich, Joachim Dong, Guang-Hui Yang, Bo-Yi |
author_facet | Qiu, Hui-Ling Fan, Shujun Zhou, Kaixin He, Zhini Browning, Matthew H.E.M. Knibbs, Luke D. Zhao, Tianyu Luo, Ya-Na Liu, Xiao-Xuan Hu, Li-Xin Li, Jia-Xin Zhang, Yi-Dan Xie, Yu-Ting Heinrich, Joachim Dong, Guang-Hui Yang, Bo-Yi |
author_sort | Qiu, Hui-Ling |
collection | PubMed |
description | Hyperglycemia is a key risk factor for death and disability worldwide. To better inform prevention strategies, we aimed to delineate and predict the temporal, spatial, and demographic patterns in mean fasting plasma glucose (FPG) levels and their related disease burden globally. Based on the Global Burden of Disease Study 2019, we estimated the distributions of mean FPG levels and high FPG-related disease burden by age, sex, year, socioeconomic status (SES), and geographical region from 1990 to 2050. We also investigated the possible associations of demographic, behavioral, dietary, metabolic, and environmental factors with FPG levels and high FPG-related disease burden. In 2019, the global mean FPG level was 5.40 mmol/L (95% uncertainty interval [UI]: 4.86–6.00), and high FPG contributed to 83.0 deaths (95% UI, 64.5–107.1) and 2,104.3 DALYs (95% UI: 1,740.7–2,520.7) per 100,000 people. For both historical (1990–2019) and future (2020–2050) periods, the mean FPG levels and the high FPG-related disease burden increased globally, with greater increases among the middle-aged and elderly, and people in low-to-middle SES countries, relative to their counterparts. Aging, unhealthy lifestyles, elevated body mass index, and lower air temperatures were potential risk factors for high FPG levels and the high FPG-related disease burden. This study demonstrates that high FPG continues to contribute to the global disease burden and is expected to do so for at least the next 30 years. Older people and those living in low-to-middle SES countries should receive more attention in glycemic management health interventions. In addition, effective interventions that target identified risk factors should be adopted to handle the increasingly large disease burden of high FPG. |
format | Online Article Text |
id | pubmed-10362522 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-103625222023-07-23 Global burden and drivers of hyperglycemia: Estimates and predictions from 1990 to 2050 Qiu, Hui-Ling Fan, Shujun Zhou, Kaixin He, Zhini Browning, Matthew H.E.M. Knibbs, Luke D. Zhao, Tianyu Luo, Ya-Na Liu, Xiao-Xuan Hu, Li-Xin Li, Jia-Xin Zhang, Yi-Dan Xie, Yu-Ting Heinrich, Joachim Dong, Guang-Hui Yang, Bo-Yi Innovation (Camb) Article Hyperglycemia is a key risk factor for death and disability worldwide. To better inform prevention strategies, we aimed to delineate and predict the temporal, spatial, and demographic patterns in mean fasting plasma glucose (FPG) levels and their related disease burden globally. Based on the Global Burden of Disease Study 2019, we estimated the distributions of mean FPG levels and high FPG-related disease burden by age, sex, year, socioeconomic status (SES), and geographical region from 1990 to 2050. We also investigated the possible associations of demographic, behavioral, dietary, metabolic, and environmental factors with FPG levels and high FPG-related disease burden. In 2019, the global mean FPG level was 5.40 mmol/L (95% uncertainty interval [UI]: 4.86–6.00), and high FPG contributed to 83.0 deaths (95% UI, 64.5–107.1) and 2,104.3 DALYs (95% UI: 1,740.7–2,520.7) per 100,000 people. For both historical (1990–2019) and future (2020–2050) periods, the mean FPG levels and the high FPG-related disease burden increased globally, with greater increases among the middle-aged and elderly, and people in low-to-middle SES countries, relative to their counterparts. Aging, unhealthy lifestyles, elevated body mass index, and lower air temperatures were potential risk factors for high FPG levels and the high FPG-related disease burden. This study demonstrates that high FPG continues to contribute to the global disease burden and is expected to do so for at least the next 30 years. Older people and those living in low-to-middle SES countries should receive more attention in glycemic management health interventions. In addition, effective interventions that target identified risk factors should be adopted to handle the increasingly large disease burden of high FPG. Elsevier 2023-05-26 /pmc/articles/PMC10362522/ /pubmed/37485083 http://dx.doi.org/10.1016/j.xinn.2023.100450 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Qiu, Hui-Ling Fan, Shujun Zhou, Kaixin He, Zhini Browning, Matthew H.E.M. Knibbs, Luke D. Zhao, Tianyu Luo, Ya-Na Liu, Xiao-Xuan Hu, Li-Xin Li, Jia-Xin Zhang, Yi-Dan Xie, Yu-Ting Heinrich, Joachim Dong, Guang-Hui Yang, Bo-Yi Global burden and drivers of hyperglycemia: Estimates and predictions from 1990 to 2050 |
title | Global burden and drivers of hyperglycemia: Estimates and predictions from 1990 to 2050 |
title_full | Global burden and drivers of hyperglycemia: Estimates and predictions from 1990 to 2050 |
title_fullStr | Global burden and drivers of hyperglycemia: Estimates and predictions from 1990 to 2050 |
title_full_unstemmed | Global burden and drivers of hyperglycemia: Estimates and predictions from 1990 to 2050 |
title_short | Global burden and drivers of hyperglycemia: Estimates and predictions from 1990 to 2050 |
title_sort | global burden and drivers of hyperglycemia: estimates and predictions from 1990 to 2050 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362522/ https://www.ncbi.nlm.nih.gov/pubmed/37485083 http://dx.doi.org/10.1016/j.xinn.2023.100450 |
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