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Enhancement of PD-L1-attenuated CAR-T cell function through breast cancer-associated fibroblasts-derived IL-6 signaling via STAT3/AKT pathways

BACKGROUND: Carcinoma-associated fibroblasts (CAFs) play a critical role in cancer progression and immune cell modulation. In this study, it was aimed to evaluate the roles of CAFs-derived IL-6 in doxorubicin (Dox) resistance and PD-L1-mediated chimeric antigenic receptor (CAR)-T cell resistance in...

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Detalles Bibliográficos
Autores principales:	Chuangchot, Nisa, Jamjuntra, Pranisa, Yangngam, Supaporn, Luangwattananun, Piriya, Thongchot, Suyanee, Junking, Mutita, Thuwajit, Peti, Yenchitsomanus, Pa-Thai, Thuwajit, Chanitra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362675/ https://www.ncbi.nlm.nih.gov/pubmed/37480115 http://dx.doi.org/10.1186/s13058-023-01684-7

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