Research progress on long non-coding RNAs for spinal cord injury

Spinal cord injury is a complex central nervous system disease with an unsatisfactory prognosis, often accompanied by multiple pathological processes. However, the underlying mechanisms of action of this disease are unclear, and there are no suitable targeted therapeutic options. Long non-coding RNA...

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Autores principales: Zhong, Musen, Fan, Guangya, An, Zhongcheng, Chen, Chen, Dong, Liqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362720/
https://www.ncbi.nlm.nih.gov/pubmed/37480035
http://dx.doi.org/10.1186/s13018-023-03989-x
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author Zhong, Musen
Fan, Guangya
An, Zhongcheng
Chen, Chen
Dong, Liqiang
author_facet Zhong, Musen
Fan, Guangya
An, Zhongcheng
Chen, Chen
Dong, Liqiang
author_sort Zhong, Musen
collection PubMed
description Spinal cord injury is a complex central nervous system disease with an unsatisfactory prognosis, often accompanied by multiple pathological processes. However, the underlying mechanisms of action of this disease are unclear, and there are no suitable targeted therapeutic options. Long non-coding RNA mediates a variety of neurological diseases and regulates various biological processes, including apoptosis and autophagy, inflammatory response, microenvironment, and oxidative stress. It is known that long non-coding RNAs have significant differences in gene expression in spinal cord injury. To further understand the mechanism of long non-coding RNA action in spinal cord injury and develop preventive and therapeutic strategies regarding spinal cord injury, this review outlines the current status of research between long non-coding RNAs and spinal cord injury and potential long non-coding RNAs targeting spinal cord injury.
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spelling pubmed-103627202023-07-23 Research progress on long non-coding RNAs for spinal cord injury Zhong, Musen Fan, Guangya An, Zhongcheng Chen, Chen Dong, Liqiang J Orthop Surg Res Review Spinal cord injury is a complex central nervous system disease with an unsatisfactory prognosis, often accompanied by multiple pathological processes. However, the underlying mechanisms of action of this disease are unclear, and there are no suitable targeted therapeutic options. Long non-coding RNA mediates a variety of neurological diseases and regulates various biological processes, including apoptosis and autophagy, inflammatory response, microenvironment, and oxidative stress. It is known that long non-coding RNAs have significant differences in gene expression in spinal cord injury. To further understand the mechanism of long non-coding RNA action in spinal cord injury and develop preventive and therapeutic strategies regarding spinal cord injury, this review outlines the current status of research between long non-coding RNAs and spinal cord injury and potential long non-coding RNAs targeting spinal cord injury. BioMed Central 2023-07-22 /pmc/articles/PMC10362720/ /pubmed/37480035 http://dx.doi.org/10.1186/s13018-023-03989-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhong, Musen
Fan, Guangya
An, Zhongcheng
Chen, Chen
Dong, Liqiang
Research progress on long non-coding RNAs for spinal cord injury
title Research progress on long non-coding RNAs for spinal cord injury
title_full Research progress on long non-coding RNAs for spinal cord injury
title_fullStr Research progress on long non-coding RNAs for spinal cord injury
title_full_unstemmed Research progress on long non-coding RNAs for spinal cord injury
title_short Research progress on long non-coding RNAs for spinal cord injury
title_sort research progress on long non-coding rnas for spinal cord injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362720/
https://www.ncbi.nlm.nih.gov/pubmed/37480035
http://dx.doi.org/10.1186/s13018-023-03989-x
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