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Copper chelation suppresses epithelial-mesenchymal transition by inhibition of canonical and non-canonical TGF-β signaling pathways in cancer
BACKGROUND: Metastatic cancer cells exploit Epithelial-mesenchymal-transition (EMT) to enhance their migration, invasion, and resistance to treatments. Recent studies highlight that elevated levels of copper are implicated in cancer progression and metastasis. Clinical trials using copper chelators...
Autores principales: | Poursani, Ensieh M., Mercatelli, Daniele, Raninga, Prahlad, Bell, Jessica L., Saletta, Federica, Kohane, Felix V., Neumann, Daniel P., Zheng, Ye, Rouaen, Jourdin R. C., Jue, Toni Rose, Michniewicz, Filip T., Schadel, Piper, Kasiou, Erin, Tsoli, Maria, Cirillo, Giuseppe, Waters, Shafagh, Shai-Hee, Tyler, Cazzoli, Riccardo, Brettle, Merryn, Slapetova, Iveta, Kasherman, Maria, Whan, Renee, Souza-Fonseca-Guimaraes, Fernando, Vahdat, Linda, Ziegler, David, Lock, John G., Giorgi, Federico M., Khanna, KumKum, Vittorio, Orazio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362738/ https://www.ncbi.nlm.nih.gov/pubmed/37480151 http://dx.doi.org/10.1186/s13578-023-01083-7 |
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