Liver metastasis from colorectal cancer: pathogenetic development, immune landscape of the tumour microenvironment and therapeutic approaches

Colorectal cancer liver metastasis (CRLM) is one of the leading causes of death among patients with colorectal cancer (CRC). Although immunotherapy has demonstrated encouraging outcomes in CRC, its benefits are minimal in CRLM. The complex immune landscape of the hepatic tumour microenvironment is e...

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Autores principales: Wang, Yaxian, Zhong, Xinyang, He, Xuefeng, Hu, Zijuan, Huang, Huixia, Chen, Jiayu, Chen, Keji, Zhao, Senlin, Wei, Ping, Li, Dawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362774/
https://www.ncbi.nlm.nih.gov/pubmed/37480104
http://dx.doi.org/10.1186/s13046-023-02729-7
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author Wang, Yaxian
Zhong, Xinyang
He, Xuefeng
Hu, Zijuan
Huang, Huixia
Chen, Jiayu
Chen, Keji
Zhao, Senlin
Wei, Ping
Li, Dawei
author_facet Wang, Yaxian
Zhong, Xinyang
He, Xuefeng
Hu, Zijuan
Huang, Huixia
Chen, Jiayu
Chen, Keji
Zhao, Senlin
Wei, Ping
Li, Dawei
author_sort Wang, Yaxian
collection PubMed
description Colorectal cancer liver metastasis (CRLM) is one of the leading causes of death among patients with colorectal cancer (CRC). Although immunotherapy has demonstrated encouraging outcomes in CRC, its benefits are minimal in CRLM. The complex immune landscape of the hepatic tumour microenvironment is essential for the development of a premetastatic niche and for the colonisation and metastasis of CRC cells; thus, an in-depth understanding of these mechanisms can provide effective immunotherapeutic targets for CRLM. This review summarises recent studies on the immune landscape of the tumour microenvironment of CRLM and highlights therapeutic prospects for targeting the suppressive immune microenvironment of CRLM.
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spelling pubmed-103627742023-07-23 Liver metastasis from colorectal cancer: pathogenetic development, immune landscape of the tumour microenvironment and therapeutic approaches Wang, Yaxian Zhong, Xinyang He, Xuefeng Hu, Zijuan Huang, Huixia Chen, Jiayu Chen, Keji Zhao, Senlin Wei, Ping Li, Dawei J Exp Clin Cancer Res Review Colorectal cancer liver metastasis (CRLM) is one of the leading causes of death among patients with colorectal cancer (CRC). Although immunotherapy has demonstrated encouraging outcomes in CRC, its benefits are minimal in CRLM. The complex immune landscape of the hepatic tumour microenvironment is essential for the development of a premetastatic niche and for the colonisation and metastasis of CRC cells; thus, an in-depth understanding of these mechanisms can provide effective immunotherapeutic targets for CRLM. This review summarises recent studies on the immune landscape of the tumour microenvironment of CRLM and highlights therapeutic prospects for targeting the suppressive immune microenvironment of CRLM. BioMed Central 2023-07-22 /pmc/articles/PMC10362774/ /pubmed/37480104 http://dx.doi.org/10.1186/s13046-023-02729-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wang, Yaxian
Zhong, Xinyang
He, Xuefeng
Hu, Zijuan
Huang, Huixia
Chen, Jiayu
Chen, Keji
Zhao, Senlin
Wei, Ping
Li, Dawei
Liver metastasis from colorectal cancer: pathogenetic development, immune landscape of the tumour microenvironment and therapeutic approaches
title Liver metastasis from colorectal cancer: pathogenetic development, immune landscape of the tumour microenvironment and therapeutic approaches
title_full Liver metastasis from colorectal cancer: pathogenetic development, immune landscape of the tumour microenvironment and therapeutic approaches
title_fullStr Liver metastasis from colorectal cancer: pathogenetic development, immune landscape of the tumour microenvironment and therapeutic approaches
title_full_unstemmed Liver metastasis from colorectal cancer: pathogenetic development, immune landscape of the tumour microenvironment and therapeutic approaches
title_short Liver metastasis from colorectal cancer: pathogenetic development, immune landscape of the tumour microenvironment and therapeutic approaches
title_sort liver metastasis from colorectal cancer: pathogenetic development, immune landscape of the tumour microenvironment and therapeutic approaches
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362774/
https://www.ncbi.nlm.nih.gov/pubmed/37480104
http://dx.doi.org/10.1186/s13046-023-02729-7
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