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Pediatric Gastrointestinal Basidiobolomycosis: A Retrospective Study from Jazan Province, Saudi Arabia

INTRODUCTION: Basidiobolomycosis is a rare fungal infection caused by Basidiobolus ranarum, and its incidence is poorly understood due to its rarity. Gastrointestinal Basidiobolomycosis (GIB) is an uncommon presentation with limited reports in Saudi Arabia. This retrospective study aims to describe...

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Autores principales: Ghazwani, Salman M, Arishi, Haidar M, Dhayhi, Nabil S, Shami, Mohammed O, Gosadi, Ibrahim M, Rajab, Moutaz, Badedi, Mohammed, Mobarki, Mousa, Alhazmi, Abdulaziz H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362874/
https://www.ncbi.nlm.nih.gov/pubmed/37484908
http://dx.doi.org/10.2147/IDR.S416213
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author Ghazwani, Salman M
Arishi, Haidar M
Dhayhi, Nabil S
Shami, Mohammed O
Gosadi, Ibrahim M
Rajab, Moutaz
Badedi, Mohammed
Mobarki, Mousa
Alhazmi, Abdulaziz H
author_facet Ghazwani, Salman M
Arishi, Haidar M
Dhayhi, Nabil S
Shami, Mohammed O
Gosadi, Ibrahim M
Rajab, Moutaz
Badedi, Mohammed
Mobarki, Mousa
Alhazmi, Abdulaziz H
author_sort Ghazwani, Salman M
collection PubMed
description INTRODUCTION: Basidiobolomycosis is a rare fungal infection caused by Basidiobolus ranarum, and its incidence is poorly understood due to its rarity. Gastrointestinal Basidiobolomycosis (GIB) is an uncommon presentation with limited reports in Saudi Arabia. This retrospective study aims to describe risk factors, clinical findings, diagnosis, and management of GIB in the pediatric population. METHODS: We conducted a retrospective analysis of all pediatric patients diagnosed with GIB at a tertiary hospital between 2010 and 2022. Patients were identified based on their diagnosis of GIB. A self-administered questionnaire was distributed to assess risk factors associated with GIB. RESULTS: We analyzed 25 cases of pediatric GIB, with approximately half of the cases (56%) occurring during the COVID-19 pandemic. The mean age of affected patients was 6.6 years, with a male predominance (60%, n=15). About 100% of parents acknowledged gecko existence in their residence, and their children were exposed to insect bites. Poor appetite was reported in all patients, and high counts of eosinophils and erythrocyte sedimentation rate were observed. Thrombocytosis was present in approximately 90% of patients, and 87% had anemia. Abdominal computerized tomography scans and ultrasound-guided biopsies were the most used diagnostic tools, with cases being diagnosed based on histopathological findings and confirmed via fungal culture. CONCLUSION: Our study provides valuable information on the potential risk factors, clinical features, diagnosis, and management of pediatric GIB in the Jazan region. The observed increase in cases during the COVID-19 pandemic highlights the need for continued surveillance and research to understand better the epidemiology and associated risk factors with this rare fungal infection. These findings emphasize the need for heightened awareness, early detection, and effective prevention strategies to mitigate the impact of pediatric GIB.
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spelling pubmed-103628742023-07-23 Pediatric Gastrointestinal Basidiobolomycosis: A Retrospective Study from Jazan Province, Saudi Arabia Ghazwani, Salman M Arishi, Haidar M Dhayhi, Nabil S Shami, Mohammed O Gosadi, Ibrahim M Rajab, Moutaz Badedi, Mohammed Mobarki, Mousa Alhazmi, Abdulaziz H Infect Drug Resist Original Research INTRODUCTION: Basidiobolomycosis is a rare fungal infection caused by Basidiobolus ranarum, and its incidence is poorly understood due to its rarity. Gastrointestinal Basidiobolomycosis (GIB) is an uncommon presentation with limited reports in Saudi Arabia. This retrospective study aims to describe risk factors, clinical findings, diagnosis, and management of GIB in the pediatric population. METHODS: We conducted a retrospective analysis of all pediatric patients diagnosed with GIB at a tertiary hospital between 2010 and 2022. Patients were identified based on their diagnosis of GIB. A self-administered questionnaire was distributed to assess risk factors associated with GIB. RESULTS: We analyzed 25 cases of pediatric GIB, with approximately half of the cases (56%) occurring during the COVID-19 pandemic. The mean age of affected patients was 6.6 years, with a male predominance (60%, n=15). About 100% of parents acknowledged gecko existence in their residence, and their children were exposed to insect bites. Poor appetite was reported in all patients, and high counts of eosinophils and erythrocyte sedimentation rate were observed. Thrombocytosis was present in approximately 90% of patients, and 87% had anemia. Abdominal computerized tomography scans and ultrasound-guided biopsies were the most used diagnostic tools, with cases being diagnosed based on histopathological findings and confirmed via fungal culture. CONCLUSION: Our study provides valuable information on the potential risk factors, clinical features, diagnosis, and management of pediatric GIB in the Jazan region. The observed increase in cases during the COVID-19 pandemic highlights the need for continued surveillance and research to understand better the epidemiology and associated risk factors with this rare fungal infection. These findings emphasize the need for heightened awareness, early detection, and effective prevention strategies to mitigate the impact of pediatric GIB. Dove 2023-07-18 /pmc/articles/PMC10362874/ /pubmed/37484908 http://dx.doi.org/10.2147/IDR.S416213 Text en © 2023 Ghazwani et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Ghazwani, Salman M
Arishi, Haidar M
Dhayhi, Nabil S
Shami, Mohammed O
Gosadi, Ibrahim M
Rajab, Moutaz
Badedi, Mohammed
Mobarki, Mousa
Alhazmi, Abdulaziz H
Pediatric Gastrointestinal Basidiobolomycosis: A Retrospective Study from Jazan Province, Saudi Arabia
title Pediatric Gastrointestinal Basidiobolomycosis: A Retrospective Study from Jazan Province, Saudi Arabia
title_full Pediatric Gastrointestinal Basidiobolomycosis: A Retrospective Study from Jazan Province, Saudi Arabia
title_fullStr Pediatric Gastrointestinal Basidiobolomycosis: A Retrospective Study from Jazan Province, Saudi Arabia
title_full_unstemmed Pediatric Gastrointestinal Basidiobolomycosis: A Retrospective Study from Jazan Province, Saudi Arabia
title_short Pediatric Gastrointestinal Basidiobolomycosis: A Retrospective Study from Jazan Province, Saudi Arabia
title_sort pediatric gastrointestinal basidiobolomycosis: a retrospective study from jazan province, saudi arabia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362874/
https://www.ncbi.nlm.nih.gov/pubmed/37484908
http://dx.doi.org/10.2147/IDR.S416213
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