Phosphorylation of αB-Crystallin Involves Interleukin-1β-Mediated Intracellular Retention in Retinal Müller Cells: A New Mechanism Underlying Fibrovascular Membrane Formation

PURPOSE: Chronic inflammation plays a pivotal role in the pathology of proliferative diabetic retinopathy (PDR), in which biological alterations of retinal glial cells are one of the key elements. The phosphorylation of αB-crystallin/CRYAB modulates its molecular dynamics and chaperone activity, and...

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Detalles Bibliográficos
Autores principales: Yamamoto, Taku, Kase, Satoru, Shinkai, Akihiro, Murata, Miyuki, Kikuchi, Kasumi, Wu, Di, Kageyama, Yasushi, Shinohara, Masami, Sasase, Tomohiko, Ishida, Susumu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
Materias:
Retinal Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362920/
https://www.ncbi.nlm.nih.gov/pubmed/37459063
http://dx.doi.org/10.1167/iovs.64.10.20

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