Regulatable Complement Inhibition of the Alternative Pathway Mitigates Wet Age-Related Macular Degeneration Pathology in a Mouse Model

PURPOSE: Risk for developing age-related macular degeneration (AMD) is linked to an overactive complement system. In the mouse model of laser-induced choroidal neovascularization (CNV), elevated levels of complement effector molecules, including complement C3, have been identified, and the alternati...

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Detalles Bibliográficos
Autores principales: Parsons, Nathaniel B., Annamalai, Balasubramaniam, Rohrer, Bärbel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
Materias:
Retina
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362922/
https://www.ncbi.nlm.nih.gov/pubmed/37462980
http://dx.doi.org/10.1167/tvst.12.7.17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362922/
https://www.ncbi.nlm.nih.gov/pubmed/37462980
http://dx.doi.org/10.1167/tvst.12.7.17

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