Decreased left heart flow in fetal lambs causes left heart hypoplasia and pro-fibrotic tissue remodeling

Low blood flow through the fetal left heart is often conjectured as an etiology for hypoplastic left heart syndrome (HLHS). To investigate if a decrease in left heart flow results in growth failure, we generate left ventricular inflow obstruction (LVIO) in mid-gestation fetal lambs by implanting coi...

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Detalles Bibliográficos
Autores principales: Reuter, Miriam S., Sokolowski, Dustin J., Javier Diaz-Mejia, J., Keunen, Johannes, de Vrijer, Barbra, Chan, Cadia, Wang, Liangxi, Ryan, Greg, Chiasson, David A., Ketela, Troy, Scherer, Stephen W., Wilson, Michael D., Jaeggi, Edgar, Chaturvedi, Rajiv R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363152/
https://www.ncbi.nlm.nih.gov/pubmed/37481629
http://dx.doi.org/10.1038/s42003-023-05132-2

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