A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation

Although the intestinal tract is a major site of reactive oxygen species (ROS) generation, the mechanisms by which antioxidant defense in gut T cells contribute to intestinal homeostasis are currently unknown. Here we show, using T cell-specific ablation of the catalytic subunit of glutamate cystein...

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Detalles Bibliográficos
Autores principales: Bonetti, Lynn, Horkova, Veronika, Longworth, Joseph, Guerra, Luana, Kurniawan, Henry, Franchina, Davide G., Soriano-Baguet, Leticia, Grusdat, Melanie, Spath, Sabine, Koncina, Eric, Ewen, Anouk, Binsfeld, Carole, Verschueren, Charlène, Gérardy, Jean-Jacques, Kobayashi, Takumi, Dostert, Catherine, Farinelle, Sophie, Härm, Janika, Chen, Ying, Harris, Isaac S., Lang, Philipp A., Vasiliou, Vasilis, Waisman, Ari, Letellier, Elisabeth, Becher, Burkhard, Mittelbronn, Michel, Brenner, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363291/
https://www.ncbi.nlm.nih.gov/pubmed/37489135
http://dx.doi.org/10.1101/2023.07.06.547932

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