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Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI)

Hispanic/Latino adults are a growing segment of the older U.S. population yet are underrepresented in brain aging research. We aimed to characterize brain aging among diverse Hispanic/Latino individuals. Hispanic/Latino individuals (unweighted n = 2273 ages 35–85 years; 56% female) from the Hispanic...

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Autores principales: Stickel, Ariana M., Tarraf, Wassim, González, Kevin A., Ivanovic, Vladamir, Paredes, Alejandra Morlett, Zeng, Donglin, Cai, Jianwen, Isasi, Carmen R., Kaplan, Robert, Lipton, Richard B., Daviglus, Martha, Testai, Fernando D., Lamar, Melissa, Gallo, Linda C., Talavera, Gregory A., Gellman, Marc D., Ramos, Alberto R., González, Hector M., DeCarli, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363333/
https://www.ncbi.nlm.nih.gov/pubmed/36933278
http://dx.doi.org/10.1016/j.neurobiolaging.2023.02.007
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author Stickel, Ariana M.
Tarraf, Wassim
González, Kevin A.
Ivanovic, Vladamir
Paredes, Alejandra Morlett
Zeng, Donglin
Cai, Jianwen
Isasi, Carmen R.
Kaplan, Robert
Lipton, Richard B.
Daviglus, Martha
Testai, Fernando D.
Lamar, Melissa
Gallo, Linda C.
Talavera, Gregory A.
Gellman, Marc D.
Ramos, Alberto R.
González, Hector M.
DeCarli, Charles
author_facet Stickel, Ariana M.
Tarraf, Wassim
González, Kevin A.
Ivanovic, Vladamir
Paredes, Alejandra Morlett
Zeng, Donglin
Cai, Jianwen
Isasi, Carmen R.
Kaplan, Robert
Lipton, Richard B.
Daviglus, Martha
Testai, Fernando D.
Lamar, Melissa
Gallo, Linda C.
Talavera, Gregory A.
Gellman, Marc D.
Ramos, Alberto R.
González, Hector M.
DeCarli, Charles
author_sort Stickel, Ariana M.
collection PubMed
description Hispanic/Latino adults are a growing segment of the older U.S. population yet are underrepresented in brain aging research. We aimed to characterize brain aging among diverse Hispanic/Latino individuals. Hispanic/Latino individuals (unweighted n = 2273 ages 35–85 years; 56% female) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) population-based study underwent magnetic resonance imaging (MRI) as part of the SOL- Investigation of Neurocognitive Aging MRI (SOL-INCA-MRI) ancillary study (2018–2022). We performed linear regressions to calculate age associations with brain volumes for each outcome (total (global) brain, hippocampal, lateral ventricle, total white matter hyperintensity (WMH), individual cortical lobar, and total cortical gray matter) and tested modification by sex. Older age was associated with smaller gray matter volumes and larger lateral ventricle and WMH volumes. Age-related differences in global brain volumes and gray matter volumes in specific regions (i.e., the hippocampus and temporal and occipital lobes) were less pronounced among women. Our findings warrant further investigation into sex-specific mechanisms of brain aging using longitudinal studies.
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spelling pubmed-103633332023-07-23 Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI) Stickel, Ariana M. Tarraf, Wassim González, Kevin A. Ivanovic, Vladamir Paredes, Alejandra Morlett Zeng, Donglin Cai, Jianwen Isasi, Carmen R. Kaplan, Robert Lipton, Richard B. Daviglus, Martha Testai, Fernando D. Lamar, Melissa Gallo, Linda C. Talavera, Gregory A. Gellman, Marc D. Ramos, Alberto R. González, Hector M. DeCarli, Charles Neurobiol Aging Article Hispanic/Latino adults are a growing segment of the older U.S. population yet are underrepresented in brain aging research. We aimed to characterize brain aging among diverse Hispanic/Latino individuals. Hispanic/Latino individuals (unweighted n = 2273 ages 35–85 years; 56% female) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) population-based study underwent magnetic resonance imaging (MRI) as part of the SOL- Investigation of Neurocognitive Aging MRI (SOL-INCA-MRI) ancillary study (2018–2022). We performed linear regressions to calculate age associations with brain volumes for each outcome (total (global) brain, hippocampal, lateral ventricle, total white matter hyperintensity (WMH), individual cortical lobar, and total cortical gray matter) and tested modification by sex. Older age was associated with smaller gray matter volumes and larger lateral ventricle and WMH volumes. Age-related differences in global brain volumes and gray matter volumes in specific regions (i.e., the hippocampus and temporal and occipital lobes) were less pronounced among women. Our findings warrant further investigation into sex-specific mechanisms of brain aging using longitudinal studies. 2023-06 2023-02-23 /pmc/articles/PMC10363333/ /pubmed/36933278 http://dx.doi.org/10.1016/j.neurobiolaging.2023.02.007 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Article
Stickel, Ariana M.
Tarraf, Wassim
González, Kevin A.
Ivanovic, Vladamir
Paredes, Alejandra Morlett
Zeng, Donglin
Cai, Jianwen
Isasi, Carmen R.
Kaplan, Robert
Lipton, Richard B.
Daviglus, Martha
Testai, Fernando D.
Lamar, Melissa
Gallo, Linda C.
Talavera, Gregory A.
Gellman, Marc D.
Ramos, Alberto R.
González, Hector M.
DeCarli, Charles
Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI)
title Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI)
title_full Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI)
title_fullStr Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI)
title_full_unstemmed Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI)
title_short Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI)
title_sort characterizing age- and sex-related differences in brain structure among middle-aged and older hispanic/latino adults in the study of latinos- investigation of neurocognitive aging magnetic resonance imaging (sol-inca mri)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363333/
https://www.ncbi.nlm.nih.gov/pubmed/36933278
http://dx.doi.org/10.1016/j.neurobiolaging.2023.02.007
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