Cargando…
Pseudotyped lentiviral vectors: Ready for translation into targeted cancer gene therapy?
Gene therapy holds great promise for curing cancer by editing the deleterious genes of tumor cells, but the lack of vector systems for efficient delivery of genetic material into specific tumor sites in vivo has limited its full therapeutic potential in cancer gene therapy. Over the past two decades...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chongqing Medical University
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363566/ https://www.ncbi.nlm.nih.gov/pubmed/37492721 http://dx.doi.org/10.1016/j.gendis.2022.03.007 |
_version_ | 1785076657840717824 |
---|---|
author | Deng, Longfei Liang, Ping Cui, Hongjuan |
author_facet | Deng, Longfei Liang, Ping Cui, Hongjuan |
author_sort | Deng, Longfei |
collection | PubMed |
description | Gene therapy holds great promise for curing cancer by editing the deleterious genes of tumor cells, but the lack of vector systems for efficient delivery of genetic material into specific tumor sites in vivo has limited its full therapeutic potential in cancer gene therapy. Over the past two decades, increasing studies have shown that lentiviral vectors (LVs) modified with different glycoproteins from a donating virus, a process referred to as pseudotyping, have altered tropism and display cell-type specificity in transduction, leading to selective tumor cell killing. This feature of LVs together with their ability to enable high efficient gene delivery in dividing and non-dividing mammalian cells in vivo make them to be attractive tools in future cancer gene therapy. This review is intended to summarize the status quo of some typical pseudotypings of LVs and their applications in basic anti-cancer studies across many malignancies. The opportunities of translating pseudotyped LVs into clinic use in cancer therapy have also been discussed. |
format | Online Article Text |
id | pubmed-10363566 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Chongqing Medical University |
record_format | MEDLINE/PubMed |
spelling | pubmed-103635662023-07-25 Pseudotyped lentiviral vectors: Ready for translation into targeted cancer gene therapy? Deng, Longfei Liang, Ping Cui, Hongjuan Genes Dis Review Article Gene therapy holds great promise for curing cancer by editing the deleterious genes of tumor cells, but the lack of vector systems for efficient delivery of genetic material into specific tumor sites in vivo has limited its full therapeutic potential in cancer gene therapy. Over the past two decades, increasing studies have shown that lentiviral vectors (LVs) modified with different glycoproteins from a donating virus, a process referred to as pseudotyping, have altered tropism and display cell-type specificity in transduction, leading to selective tumor cell killing. This feature of LVs together with their ability to enable high efficient gene delivery in dividing and non-dividing mammalian cells in vivo make them to be attractive tools in future cancer gene therapy. This review is intended to summarize the status quo of some typical pseudotypings of LVs and their applications in basic anti-cancer studies across many malignancies. The opportunities of translating pseudotyped LVs into clinic use in cancer therapy have also been discussed. Chongqing Medical University 2022-04-02 /pmc/articles/PMC10363566/ /pubmed/37492721 http://dx.doi.org/10.1016/j.gendis.2022.03.007 Text en © 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Deng, Longfei Liang, Ping Cui, Hongjuan Pseudotyped lentiviral vectors: Ready for translation into targeted cancer gene therapy? |
title | Pseudotyped lentiviral vectors: Ready for translation into targeted cancer gene therapy? |
title_full | Pseudotyped lentiviral vectors: Ready for translation into targeted cancer gene therapy? |
title_fullStr | Pseudotyped lentiviral vectors: Ready for translation into targeted cancer gene therapy? |
title_full_unstemmed | Pseudotyped lentiviral vectors: Ready for translation into targeted cancer gene therapy? |
title_short | Pseudotyped lentiviral vectors: Ready for translation into targeted cancer gene therapy? |
title_sort | pseudotyped lentiviral vectors: ready for translation into targeted cancer gene therapy? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363566/ https://www.ncbi.nlm.nih.gov/pubmed/37492721 http://dx.doi.org/10.1016/j.gendis.2022.03.007 |
work_keys_str_mv | AT denglongfei pseudotypedlentiviralvectorsreadyfortranslationintotargetedcancergenetherapy AT liangping pseudotypedlentiviralvectorsreadyfortranslationintotargetedcancergenetherapy AT cuihongjuan pseudotypedlentiviralvectorsreadyfortranslationintotargetedcancergenetherapy |