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Could probiotics protect against human toxicity caused by polystyrene nanoplastics and microplastics?

Nanoplastics (NPs) and microplastics (MPs) made of polystyrene (PS) can be toxic to humans, especially by ingestion of plastic particles. These substances are often introduced into the gastrointestinal tract, where they can cause several adverse effects, including disturbances in intestinal flora, m...

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Autores principales: Bazeli, Javad, Banikazemi, Zarrin, Hamblin, Michael R., Sharafati Chaleshtori, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363603/
https://www.ncbi.nlm.nih.gov/pubmed/37492595
http://dx.doi.org/10.3389/fnut.2023.1186724
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author Bazeli, Javad
Banikazemi, Zarrin
Hamblin, Michael R.
Sharafati Chaleshtori, Reza
author_facet Bazeli, Javad
Banikazemi, Zarrin
Hamblin, Michael R.
Sharafati Chaleshtori, Reza
author_sort Bazeli, Javad
collection PubMed
description Nanoplastics (NPs) and microplastics (MPs) made of polystyrene (PS) can be toxic to humans, especially by ingestion of plastic particles. These substances are often introduced into the gastrointestinal tract, where they can cause several adverse effects, including disturbances in intestinal flora, mutagenicity, cytotoxicity, reproductive toxicity, neurotoxicity, and exacerbated oxidative stress. Although there are widespread reports of the protective effects of probiotics on the harm caused by chemical contaminants, limited information is available on how these organisms may protect against PS toxicity in either humans or animals. The protective effects of probiotics can be seen in organs, such as the gastrointestinal tract, reproductive tract, and even the brain. It has been shown that both MPs and NPs could induce microbial dysbiosis in the gut, nose and lungs, and probiotic bacteria could be considered for both prevention and treatment. Furthermore, the improvement in gut dysbiosis and intestinal leakage after probiotics consumption may reduce inflammatory biomarkers and avoid unnecessary activation of the immune system. Herein, we show probiotics may overcome the toxicity of polystyrene nanoplastics and microplastics in humans, although some studies are required before any clinical recommendations can be made.
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spelling pubmed-103636032023-07-25 Could probiotics protect against human toxicity caused by polystyrene nanoplastics and microplastics? Bazeli, Javad Banikazemi, Zarrin Hamblin, Michael R. Sharafati Chaleshtori, Reza Front Nutr Nutrition Nanoplastics (NPs) and microplastics (MPs) made of polystyrene (PS) can be toxic to humans, especially by ingestion of plastic particles. These substances are often introduced into the gastrointestinal tract, where they can cause several adverse effects, including disturbances in intestinal flora, mutagenicity, cytotoxicity, reproductive toxicity, neurotoxicity, and exacerbated oxidative stress. Although there are widespread reports of the protective effects of probiotics on the harm caused by chemical contaminants, limited information is available on how these organisms may protect against PS toxicity in either humans or animals. The protective effects of probiotics can be seen in organs, such as the gastrointestinal tract, reproductive tract, and even the brain. It has been shown that both MPs and NPs could induce microbial dysbiosis in the gut, nose and lungs, and probiotic bacteria could be considered for both prevention and treatment. Furthermore, the improvement in gut dysbiosis and intestinal leakage after probiotics consumption may reduce inflammatory biomarkers and avoid unnecessary activation of the immune system. Herein, we show probiotics may overcome the toxicity of polystyrene nanoplastics and microplastics in humans, although some studies are required before any clinical recommendations can be made. Frontiers Media S.A. 2023-07-10 /pmc/articles/PMC10363603/ /pubmed/37492595 http://dx.doi.org/10.3389/fnut.2023.1186724 Text en Copyright © 2023 Bazeli, Banikazemi, Hamblin and Sharafati Chaleshtori. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Bazeli, Javad
Banikazemi, Zarrin
Hamblin, Michael R.
Sharafati Chaleshtori, Reza
Could probiotics protect against human toxicity caused by polystyrene nanoplastics and microplastics?
title Could probiotics protect against human toxicity caused by polystyrene nanoplastics and microplastics?
title_full Could probiotics protect against human toxicity caused by polystyrene nanoplastics and microplastics?
title_fullStr Could probiotics protect against human toxicity caused by polystyrene nanoplastics and microplastics?
title_full_unstemmed Could probiotics protect against human toxicity caused by polystyrene nanoplastics and microplastics?
title_short Could probiotics protect against human toxicity caused by polystyrene nanoplastics and microplastics?
title_sort could probiotics protect against human toxicity caused by polystyrene nanoplastics and microplastics?
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363603/
https://www.ncbi.nlm.nih.gov/pubmed/37492595
http://dx.doi.org/10.3389/fnut.2023.1186724
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