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Mechanism of PGC-1α-mediated mitochondrial biogenesis in cerebral ischemia–reperfusion injury
Cerebral ischemia–reperfusion injury (CIRI) is a series of cascade reactions that occur after blood flow recanalization in the ischemic zone in patients with cerebral infarction, causing an imbalance in intracellular homeostasis through multiple pathologies such as increased oxygen free radicals, in...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363604/ https://www.ncbi.nlm.nih.gov/pubmed/37492523 http://dx.doi.org/10.3389/fnmol.2023.1224964 |
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author | Yuan, Ying Tian, Yuan Jiang, Hui Cai, Luo-yang Song, Jie Peng, Rui Zhang, Xiao-ming |
author_facet | Yuan, Ying Tian, Yuan Jiang, Hui Cai, Luo-yang Song, Jie Peng, Rui Zhang, Xiao-ming |
author_sort | Yuan, Ying |
collection | PubMed |
description | Cerebral ischemia–reperfusion injury (CIRI) is a series of cascade reactions that occur after blood flow recanalization in the ischemic zone in patients with cerebral infarction, causing an imbalance in intracellular homeostasis through multiple pathologies such as increased oxygen free radicals, inflammatory response, calcium overload, and impaired energy metabolism, leading to mitochondrial dysfunction and ultimately apoptosis. Rescue of reversibly damaged neurons in the ischemic hemispheric zone is the key to saving brain infarction and reducing neurological deficits. Complex and active neurological functions are highly dependent on an adequate energy supply from mitochondria. Mitochondrial biogenesis (MB), a process that generates new functional mitochondria and restores normal mitochondrial function by replacing damaged mitochondria, is a major mechanism for maintaining intra-mitochondrial homeostasis and is involved in mitochondrial quality control to ameliorate mitochondrial dysfunction and thus protects against CIRI. The main regulator of MB is peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), which improves mitochondrial function to protect against CIRI by activating its downstream nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (TFAM) to promote mitochondrial genome replication and transcription. This paper provides a theoretical reference for the treatment of neurological impairment caused by CIRI by discussing the mechanisms of mitochondrial biogenesis during cerebral ischemia–reperfusion injury. |
format | Online Article Text |
id | pubmed-10363604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103636042023-07-25 Mechanism of PGC-1α-mediated mitochondrial biogenesis in cerebral ischemia–reperfusion injury Yuan, Ying Tian, Yuan Jiang, Hui Cai, Luo-yang Song, Jie Peng, Rui Zhang, Xiao-ming Front Mol Neurosci Molecular Neuroscience Cerebral ischemia–reperfusion injury (CIRI) is a series of cascade reactions that occur after blood flow recanalization in the ischemic zone in patients with cerebral infarction, causing an imbalance in intracellular homeostasis through multiple pathologies such as increased oxygen free radicals, inflammatory response, calcium overload, and impaired energy metabolism, leading to mitochondrial dysfunction and ultimately apoptosis. Rescue of reversibly damaged neurons in the ischemic hemispheric zone is the key to saving brain infarction and reducing neurological deficits. Complex and active neurological functions are highly dependent on an adequate energy supply from mitochondria. Mitochondrial biogenesis (MB), a process that generates new functional mitochondria and restores normal mitochondrial function by replacing damaged mitochondria, is a major mechanism for maintaining intra-mitochondrial homeostasis and is involved in mitochondrial quality control to ameliorate mitochondrial dysfunction and thus protects against CIRI. The main regulator of MB is peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), which improves mitochondrial function to protect against CIRI by activating its downstream nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (TFAM) to promote mitochondrial genome replication and transcription. This paper provides a theoretical reference for the treatment of neurological impairment caused by CIRI by discussing the mechanisms of mitochondrial biogenesis during cerebral ischemia–reperfusion injury. Frontiers Media S.A. 2023-07-10 /pmc/articles/PMC10363604/ /pubmed/37492523 http://dx.doi.org/10.3389/fnmol.2023.1224964 Text en Copyright © 2023 Yuan, Tian, Jiang, Cai, Song, Peng and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Neuroscience Yuan, Ying Tian, Yuan Jiang, Hui Cai, Luo-yang Song, Jie Peng, Rui Zhang, Xiao-ming Mechanism of PGC-1α-mediated mitochondrial biogenesis in cerebral ischemia–reperfusion injury |
title | Mechanism of PGC-1α-mediated mitochondrial biogenesis in cerebral ischemia–reperfusion injury |
title_full | Mechanism of PGC-1α-mediated mitochondrial biogenesis in cerebral ischemia–reperfusion injury |
title_fullStr | Mechanism of PGC-1α-mediated mitochondrial biogenesis in cerebral ischemia–reperfusion injury |
title_full_unstemmed | Mechanism of PGC-1α-mediated mitochondrial biogenesis in cerebral ischemia–reperfusion injury |
title_short | Mechanism of PGC-1α-mediated mitochondrial biogenesis in cerebral ischemia–reperfusion injury |
title_sort | mechanism of pgc-1α-mediated mitochondrial biogenesis in cerebral ischemia–reperfusion injury |
topic | Molecular Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363604/ https://www.ncbi.nlm.nih.gov/pubmed/37492523 http://dx.doi.org/10.3389/fnmol.2023.1224964 |
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