Identification of novel and potent dual-targeting HDAC1/SPOP inhibitors using structure-based virtual screening, molecular dynamics simulation and evaluation of in vitro and in vivo antitumor activity

Cancer is one of the important factors threatening human health. Hence, it is essential to create novel potent drugs to treat it. Due to the strong correlation among histone deacetylase1 (HDAC1), speckle-type POZ protein (SPOP) and cancers, dual inhibition of HDAC1 and SPOP may be a promising strate...

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Detalles Bibliográficos
Autores principales: Yang, Yingxue, Chen, Shutong, Wang, Qinghua, Niu, Miao-Miao, Qu, Yuanqian, Zhou, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363607/
https://www.ncbi.nlm.nih.gov/pubmed/37492092
http://dx.doi.org/10.3389/fphar.2023.1208740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363607/
https://www.ncbi.nlm.nih.gov/pubmed/37492092
http://dx.doi.org/10.3389/fphar.2023.1208740

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