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Optogenetic modulation of guanine nucleotide exchange factors of Ras superfamily proteins directly controls cell shape and movement

In this article, we provide detailed protocols on using optogenetic dimerizers to acutely perturb activities of guanine nucleotide exchange factors (GEFs) specific to Ras, Rac or Rho small GTPases of the migratory networks in various mammalian and amoeba cell lines. These GEFs are crucial components...

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Detalles Bibliográficos
Autores principales:	Pal, Dhiman Sankar, Lin, Yiyan, Zhan, Huiwang, Banerjee, Tatsat, Kuhn, Jonathan, Providence, Stephenie, Devreotes, Peter N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363612/ https://www.ncbi.nlm.nih.gov/pubmed/37492221 http://dx.doi.org/10.3389/fcell.2023.1195806

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