Impact of supraphysiologic MDM2 expression on chromatin networks and therapeutic responses in sarcoma

Amplification of MDM2 on supernumerary chromosomes is a common mechanism of P53 inactivation across tumors. Here, we investigated the impact of MDM2 overexpression on chromatin, gene expression, and cellular phenotypes in liposarcoma. Three independent regulatory circuits predominate in aggressive,...

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Detalles Bibliográficos
Autores principales: Bevill, Samantha M., Casaní-Galdón, Salvador, El Farran, Chadi A., Cytrynbaum, Eli G., Macias, Kevin A., Oldeman, Sylvie E., Oliveira, Kayla J., Moore, Molly M., Hegazi, Esmat, Adriaens, Carmen, Najm, Fadi J., Demetri, George D., Cohen, Sonia, Mullen, John T., Riggi, Nicolò, Johnstone, Sarah E., Bernstein, Bradley E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363746/
https://www.ncbi.nlm.nih.gov/pubmed/37492096
http://dx.doi.org/10.1016/j.xgen.2023.100321

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