Curcumin-loaded mesoporous silica nanoparticles for drug delivery: synthesis, biological assays and therapeutic potential – a review

Curcumin-loaded mesoporous silica nanoparticles (MSNs) have shown promise as drug delivery systems to address the limited pharmacokinetic characteristics of curcumin. Functionalization with folic acid and PEGylation enhance anticancer activity, biocompatibility, stability, and permeability. Co-deliv...

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Autores principales: Iranshahy, Milad, Hanafi-Bojd, Mohammad Yahya, Aghili, Seyed Hadi, Iranshahi, Mehrdad, Nabavi, Seyed Mohammad, Saberi, Satar, Filosa, Rosanna, Nezhad, Iman Farzam, Hasanpour, Maede
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363773/
https://www.ncbi.nlm.nih.gov/pubmed/37492509
http://dx.doi.org/10.1039/d3ra02772d
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author Iranshahy, Milad
Hanafi-Bojd, Mohammad Yahya
Aghili, Seyed Hadi
Iranshahi, Mehrdad
Nabavi, Seyed Mohammad
Saberi, Satar
Filosa, Rosanna
Nezhad, Iman Farzam
Hasanpour, Maede
author_facet Iranshahy, Milad
Hanafi-Bojd, Mohammad Yahya
Aghili, Seyed Hadi
Iranshahi, Mehrdad
Nabavi, Seyed Mohammad
Saberi, Satar
Filosa, Rosanna
Nezhad, Iman Farzam
Hasanpour, Maede
author_sort Iranshahy, Milad
collection PubMed
description Curcumin-loaded mesoporous silica nanoparticles (MSNs) have shown promise as drug delivery systems to address the limited pharmacokinetic characteristics of curcumin. Functionalization with folic acid and PEGylation enhance anticancer activity, biocompatibility, stability, and permeability. Co-delivery with other drugs results in synergistically enhanced cytotoxic activity. Environment-responsive MSNs prevent undesirable drug leakage and increase selectivity towards target tissues. This review summarizes the methods of Cur-loaded MSN synthesis and functionalization and their application in various diseases, and also highlights the potential of Cur-loaded MSNs as a promising drug delivery system.
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spelling pubmed-103637732023-07-25 Curcumin-loaded mesoporous silica nanoparticles for drug delivery: synthesis, biological assays and therapeutic potential – a review Iranshahy, Milad Hanafi-Bojd, Mohammad Yahya Aghili, Seyed Hadi Iranshahi, Mehrdad Nabavi, Seyed Mohammad Saberi, Satar Filosa, Rosanna Nezhad, Iman Farzam Hasanpour, Maede RSC Adv Chemistry Curcumin-loaded mesoporous silica nanoparticles (MSNs) have shown promise as drug delivery systems to address the limited pharmacokinetic characteristics of curcumin. Functionalization with folic acid and PEGylation enhance anticancer activity, biocompatibility, stability, and permeability. Co-delivery with other drugs results in synergistically enhanced cytotoxic activity. Environment-responsive MSNs prevent undesirable drug leakage and increase selectivity towards target tissues. This review summarizes the methods of Cur-loaded MSN synthesis and functionalization and their application in various diseases, and also highlights the potential of Cur-loaded MSNs as a promising drug delivery system. The Royal Society of Chemistry 2023-07-24 /pmc/articles/PMC10363773/ /pubmed/37492509 http://dx.doi.org/10.1039/d3ra02772d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Iranshahy, Milad
Hanafi-Bojd, Mohammad Yahya
Aghili, Seyed Hadi
Iranshahi, Mehrdad
Nabavi, Seyed Mohammad
Saberi, Satar
Filosa, Rosanna
Nezhad, Iman Farzam
Hasanpour, Maede
Curcumin-loaded mesoporous silica nanoparticles for drug delivery: synthesis, biological assays and therapeutic potential – a review
title Curcumin-loaded mesoporous silica nanoparticles for drug delivery: synthesis, biological assays and therapeutic potential – a review
title_full Curcumin-loaded mesoporous silica nanoparticles for drug delivery: synthesis, biological assays and therapeutic potential – a review
title_fullStr Curcumin-loaded mesoporous silica nanoparticles for drug delivery: synthesis, biological assays and therapeutic potential – a review
title_full_unstemmed Curcumin-loaded mesoporous silica nanoparticles for drug delivery: synthesis, biological assays and therapeutic potential – a review
title_short Curcumin-loaded mesoporous silica nanoparticles for drug delivery: synthesis, biological assays and therapeutic potential – a review
title_sort curcumin-loaded mesoporous silica nanoparticles for drug delivery: synthesis, biological assays and therapeutic potential – a review
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363773/
https://www.ncbi.nlm.nih.gov/pubmed/37492509
http://dx.doi.org/10.1039/d3ra02772d
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