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Design, synthesis, in silico studies, and biological evaluation of novel pyrimidine-5-carbonitrile derivatives as potential anti-proliferative agents, VEGFR-2 inhibitors and apoptotic inducers

A novel series of pyrimidine-5-carbonitrile derivatives bearing benzylidene and hydrazone moieties with different linkers (spacers) were designed and synthesized as possible inhibitors of the vascular endothelial growth factor receptor-2 (VEGFR-2). The newly synthesized compounds were evaluated in v...

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Detalles Bibliográficos
Autores principales:	Saleh, Abdulrahman M., Mahdy, Hazem A., El-Zahabi, Mohamed Ayman, Mehany, Ahmed B. M., Khalifa, Mohamed M., Eissa, Ibrahim H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363774/ https://www.ncbi.nlm.nih.gov/pubmed/37492514 http://dx.doi.org/10.1039/d3ra04182d

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