Cargando…
Clinical characteristics and serum inflammatory markers of community‐acquired mycoplasma pneumonia in children
BACKGROUND: To compare the demographic and clinical features, laboratory and imaging findings in mycoplasma pneumoniae pneumonia (MPP) children with non‐MPP (NMPP) children and general MPP (GMPP) children with refractory MPP (RMPP) children and analysis the relationship with the severity of disease....
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363789/ https://www.ncbi.nlm.nih.gov/pubmed/37142438 http://dx.doi.org/10.1111/crj.13620 |
_version_ | 1785076709348868096 |
---|---|
author | Fan, Fei Lv, Jun Yang, Qianyuan Jiang, Fei |
author_facet | Fan, Fei Lv, Jun Yang, Qianyuan Jiang, Fei |
author_sort | Fan, Fei |
collection | PubMed |
description | BACKGROUND: To compare the demographic and clinical features, laboratory and imaging findings in mycoplasma pneumoniae pneumonia (MPP) children with non‐MPP (NMPP) children and general MPP (GMPP) children with refractory MPP (RMPP) children and analysis the relationship with the severity of disease. METHODS: The study included 265 children with MPP and 230 children with NMPP in the Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University from 2020 to 2021. The children with MPP included RMPP (n = 85) and GMPP (n = 180). Demographic and clinical characteristics, laboratory and imaging findings of all children were measured as baseline data within 24 h after admission and the differences between MPP and NMPP, RMPP and GMPP patients were compared. ROC curves were used to evaluate the diagnostic and predictive value of different indicators for RMPP. RESULTS: Fever duration and hospital stay in children with MPP were longer than those with NMPP. The number of patients with imaging features of pleural effusion, lung consolidation and bronchopneumonia in MPP group was significantly higher than that in NMPP group. Compared with NMPP group, the levels of C‐reactive protein (CRP), procalcitonin (PCT), serum amyloid A (SAA), erythrocyte sedimentation rate (ESR), lactic dehydrogenase (LDH), prothrombin time (PT), fibrinogen (FIB) and D‐dimer and inflammatory cytokines (interleukin [IL]‐6, IL‐8, IL‐10 and IL‐1β) in MPP group were significantly higher (P < 0.05). The clinical symptoms and pulmonary imaging findings were more severe in RMPP group. The levels of white blood cell (WBC), CRP, PCT, SAA, ESR, alanine aminotransferase (ALT), LDH, ferritin, PT, FIB, D‐dimer and inflammatory cytokines in RMPP group were higher than those in GMPP group. There was no significant difference in the level of lymphocyte subsets between the RMPP and GMPP group. IL‐6, IL‐10, LDH, PT, D‐dimer and lung consolidation were independent risk factors for RMPP. IL‐6 levels and LDH activity were good predictors of RMPP. CONCLUSION: In conclusion, there were differences in clinical characteristics and serum inflammatory markers between MPP group and NMPP group, RMPP group and GMPP group. IL‐6, IL‐10, LDH, PT and D‐dimer can be used as predictive indicators for RMPP. |
format | Online Article Text |
id | pubmed-10363789 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103637892023-07-25 Clinical characteristics and serum inflammatory markers of community‐acquired mycoplasma pneumonia in children Fan, Fei Lv, Jun Yang, Qianyuan Jiang, Fei Clin Respir J Original Articles BACKGROUND: To compare the demographic and clinical features, laboratory and imaging findings in mycoplasma pneumoniae pneumonia (MPP) children with non‐MPP (NMPP) children and general MPP (GMPP) children with refractory MPP (RMPP) children and analysis the relationship with the severity of disease. METHODS: The study included 265 children with MPP and 230 children with NMPP in the Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University from 2020 to 2021. The children with MPP included RMPP (n = 85) and GMPP (n = 180). Demographic and clinical characteristics, laboratory and imaging findings of all children were measured as baseline data within 24 h after admission and the differences between MPP and NMPP, RMPP and GMPP patients were compared. ROC curves were used to evaluate the diagnostic and predictive value of different indicators for RMPP. RESULTS: Fever duration and hospital stay in children with MPP were longer than those with NMPP. The number of patients with imaging features of pleural effusion, lung consolidation and bronchopneumonia in MPP group was significantly higher than that in NMPP group. Compared with NMPP group, the levels of C‐reactive protein (CRP), procalcitonin (PCT), serum amyloid A (SAA), erythrocyte sedimentation rate (ESR), lactic dehydrogenase (LDH), prothrombin time (PT), fibrinogen (FIB) and D‐dimer and inflammatory cytokines (interleukin [IL]‐6, IL‐8, IL‐10 and IL‐1β) in MPP group were significantly higher (P < 0.05). The clinical symptoms and pulmonary imaging findings were more severe in RMPP group. The levels of white blood cell (WBC), CRP, PCT, SAA, ESR, alanine aminotransferase (ALT), LDH, ferritin, PT, FIB, D‐dimer and inflammatory cytokines in RMPP group were higher than those in GMPP group. There was no significant difference in the level of lymphocyte subsets between the RMPP and GMPP group. IL‐6, IL‐10, LDH, PT, D‐dimer and lung consolidation were independent risk factors for RMPP. IL‐6 levels and LDH activity were good predictors of RMPP. CONCLUSION: In conclusion, there were differences in clinical characteristics and serum inflammatory markers between MPP group and NMPP group, RMPP group and GMPP group. IL‐6, IL‐10, LDH, PT and D‐dimer can be used as predictive indicators for RMPP. John Wiley and Sons Inc. 2023-05-04 /pmc/articles/PMC10363789/ /pubmed/37142438 http://dx.doi.org/10.1111/crj.13620 Text en © 2023 The Authors. The Clinical Respiratory Journal published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Fan, Fei Lv, Jun Yang, Qianyuan Jiang, Fei Clinical characteristics and serum inflammatory markers of community‐acquired mycoplasma pneumonia in children |
title | Clinical characteristics and serum inflammatory markers of community‐acquired mycoplasma pneumonia in children |
title_full | Clinical characteristics and serum inflammatory markers of community‐acquired mycoplasma pneumonia in children |
title_fullStr | Clinical characteristics and serum inflammatory markers of community‐acquired mycoplasma pneumonia in children |
title_full_unstemmed | Clinical characteristics and serum inflammatory markers of community‐acquired mycoplasma pneumonia in children |
title_short | Clinical characteristics and serum inflammatory markers of community‐acquired mycoplasma pneumonia in children |
title_sort | clinical characteristics and serum inflammatory markers of community‐acquired mycoplasma pneumonia in children |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363789/ https://www.ncbi.nlm.nih.gov/pubmed/37142438 http://dx.doi.org/10.1111/crj.13620 |
work_keys_str_mv | AT fanfei clinicalcharacteristicsandseruminflammatorymarkersofcommunityacquiredmycoplasmapneumoniainchildren AT lvjun clinicalcharacteristicsandseruminflammatorymarkersofcommunityacquiredmycoplasmapneumoniainchildren AT yangqianyuan clinicalcharacteristicsandseruminflammatorymarkersofcommunityacquiredmycoplasmapneumoniainchildren AT jiangfei clinicalcharacteristicsandseruminflammatorymarkersofcommunityacquiredmycoplasmapneumoniainchildren |