150 risk variants for diverticular disease of intestine prioritize cell types and enable polygenic prediction of disease susceptibility

We conducted a genome-wide association study (GWAS) analysis of diverticular disease (DivD) of intestine within 724,372 individuals and identified 150 independent genome-wide significant DNA variants. Integration of the GWAS results with human gut single-cell RNA sequencing data implicated gut myocy...

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Detalles Bibliográficos
Autores principales: Wu, Yeda, Goleva, Slavina B., Breidenbach, Lindsay B., Kim, Minsoo, MacGregor, Stuart, Gandal, Michael J., Davis, Lea K., Wray, Naomi R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363821/
https://www.ncbi.nlm.nih.gov/pubmed/37492107
http://dx.doi.org/10.1016/j.xgen.2023.100326

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