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Effects of synovial macrophages in osteoarthritis
Osteoarthritis (OA) is a common degenerative disease in mammals. However, its pathogenesis remains unclear. Studies indicate that OA is not only an aging process that but also an inflammation-related disease. Synovitis is closely related to the progression of OA, and synovial macrophages are crucial...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364050/ https://www.ncbi.nlm.nih.gov/pubmed/37492583 http://dx.doi.org/10.3389/fimmu.2023.1164137 |
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author | Zhao, Kun Ruan, Jiaqi Nie, Liuyan Ye, Xiangming Li, Juebao |
author_facet | Zhao, Kun Ruan, Jiaqi Nie, Liuyan Ye, Xiangming Li, Juebao |
author_sort | Zhao, Kun |
collection | PubMed |
description | Osteoarthritis (OA) is a common degenerative disease in mammals. However, its pathogenesis remains unclear. Studies indicate that OA is not only an aging process that but also an inflammation-related disease. Synovitis is closely related to the progression of OA, and synovial macrophages are crucial participants in synovitis. Instead of being a homogeneous population, macrophages are polarized into M1 or M2 subtypes in OA synovial tissues. Polarization is highly associated with OA severity. However, the M1/M2 ratio cannot be the only factor in OA prognosis because intermediate stages of macrophages also exist. To better understand the mechanism of this heterogeneous disease, OA subtypes of synovial macrophages classified by gene expression were examined. Synovial macrophages do not act alone; they interact with surrounding cells such as synovial fibroblasts, osteoclasts, chondrocytes, lymphocytes and even adipose cells through a paracrine approach to exacerbate OA. Treatments targeting synovial macrophages and their polarization are effective in relieving pain and protecting cartilage during OA development. In this review, we describe how synovial macrophages and their different polarization states influence the progression of OA. We summarize the current knowledge of the interactions between macrophages and other joint cells and examine the current research on new medications targeting synovial macrophages. |
format | Online Article Text |
id | pubmed-10364050 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103640502023-07-25 Effects of synovial macrophages in osteoarthritis Zhao, Kun Ruan, Jiaqi Nie, Liuyan Ye, Xiangming Li, Juebao Front Immunol Immunology Osteoarthritis (OA) is a common degenerative disease in mammals. However, its pathogenesis remains unclear. Studies indicate that OA is not only an aging process that but also an inflammation-related disease. Synovitis is closely related to the progression of OA, and synovial macrophages are crucial participants in synovitis. Instead of being a homogeneous population, macrophages are polarized into M1 or M2 subtypes in OA synovial tissues. Polarization is highly associated with OA severity. However, the M1/M2 ratio cannot be the only factor in OA prognosis because intermediate stages of macrophages also exist. To better understand the mechanism of this heterogeneous disease, OA subtypes of synovial macrophages classified by gene expression were examined. Synovial macrophages do not act alone; they interact with surrounding cells such as synovial fibroblasts, osteoclasts, chondrocytes, lymphocytes and even adipose cells through a paracrine approach to exacerbate OA. Treatments targeting synovial macrophages and their polarization are effective in relieving pain and protecting cartilage during OA development. In this review, we describe how synovial macrophages and their different polarization states influence the progression of OA. We summarize the current knowledge of the interactions between macrophages and other joint cells and examine the current research on new medications targeting synovial macrophages. Frontiers Media S.A. 2023-07-10 /pmc/articles/PMC10364050/ /pubmed/37492583 http://dx.doi.org/10.3389/fimmu.2023.1164137 Text en Copyright © 2023 Zhao, Ruan, Nie, Ye and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Zhao, Kun Ruan, Jiaqi Nie, Liuyan Ye, Xiangming Li, Juebao Effects of synovial macrophages in osteoarthritis |
title | Effects of synovial macrophages in osteoarthritis |
title_full | Effects of synovial macrophages in osteoarthritis |
title_fullStr | Effects of synovial macrophages in osteoarthritis |
title_full_unstemmed | Effects of synovial macrophages in osteoarthritis |
title_short | Effects of synovial macrophages in osteoarthritis |
title_sort | effects of synovial macrophages in osteoarthritis |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364050/ https://www.ncbi.nlm.nih.gov/pubmed/37492583 http://dx.doi.org/10.3389/fimmu.2023.1164137 |
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