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Weight variation increases the risk of death during the intensive phase of treatment among MDR-TB patients: A retrospective study
OBJECTIVE: To estimate the predictors of death during intensive phase of Multidrug resistant tuberculosis treatment according to the weight of patients at the time of diagnosed. METHODS: A retrospective study was conducted at three public hospitals in the Lahore, Punjab region, namely Jinnah Hospita...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Professional Medical Publications
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364273/ https://www.ncbi.nlm.nih.gov/pubmed/37492339 http://dx.doi.org/10.12669/pjms.39.4.7025 |
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author | Akhtar, Abdul Majeed Kanwal, Shamsa Majeed, Sufia Majeed, Wasif |
author_facet | Akhtar, Abdul Majeed Kanwal, Shamsa Majeed, Sufia Majeed, Wasif |
author_sort | Akhtar, Abdul Majeed |
collection | PubMed |
description | OBJECTIVE: To estimate the predictors of death during intensive phase of Multidrug resistant tuberculosis treatment according to the weight of patients at the time of diagnosed. METHODS: A retrospective study was conducted at three public hospitals in the Lahore, Punjab region, namely Jinnah Hospital, Mayo Hospital and Gulab Devi Hospital on 1,496 patients receiving treatment for MDR-TB from January 2018 to December 2020. Data were collected from electronically nominating and recording system of the hospitals. Data were fitted to Cox proportional hazards regression model with 95% confidence interval (CI) to evaluate the associations between predictors of death and weight of MDR-TB patients during the intensive phase of treatment. RESULTS: This analysis revealed a MDR-TB mortality rate of 30% and the mortality rate due to MDR-TB during the intensive phase of treatment was 23%. The variables related to increased mortality among underweight patients were age more than 60 years (HR: 0.398, 95% CI: 0.314-0.504) , diabetes (HR: 1.496, 95% CI: 1.165-1.921), current smoking (HR: 0.465, 95% CI: 0.222-0.973), history of MDR-TB (HR: 0.701, 95% CI: 0.512-0.959) and culture positive at the time of diagnosed (HR: 0.499, 95% CI: 0.379-0.659) during the intensive phase of treatment. CONCLUSION: The high mortality rate among the underweight MDR-TB patients during the intensive phase of the treatment requires the nutritional support for malnourishment and ensured a close follow-up of the elderly patients with co-morbidities as well as family history of Tuberculosis. |
format | Online Article Text |
id | pubmed-10364273 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Professional Medical Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-103642732023-07-25 Weight variation increases the risk of death during the intensive phase of treatment among MDR-TB patients: A retrospective study Akhtar, Abdul Majeed Kanwal, Shamsa Majeed, Sufia Majeed, Wasif Pak J Med Sci Original Article OBJECTIVE: To estimate the predictors of death during intensive phase of Multidrug resistant tuberculosis treatment according to the weight of patients at the time of diagnosed. METHODS: A retrospective study was conducted at three public hospitals in the Lahore, Punjab region, namely Jinnah Hospital, Mayo Hospital and Gulab Devi Hospital on 1,496 patients receiving treatment for MDR-TB from January 2018 to December 2020. Data were collected from electronically nominating and recording system of the hospitals. Data were fitted to Cox proportional hazards regression model with 95% confidence interval (CI) to evaluate the associations between predictors of death and weight of MDR-TB patients during the intensive phase of treatment. RESULTS: This analysis revealed a MDR-TB mortality rate of 30% and the mortality rate due to MDR-TB during the intensive phase of treatment was 23%. The variables related to increased mortality among underweight patients were age more than 60 years (HR: 0.398, 95% CI: 0.314-0.504) , diabetes (HR: 1.496, 95% CI: 1.165-1.921), current smoking (HR: 0.465, 95% CI: 0.222-0.973), history of MDR-TB (HR: 0.701, 95% CI: 0.512-0.959) and culture positive at the time of diagnosed (HR: 0.499, 95% CI: 0.379-0.659) during the intensive phase of treatment. CONCLUSION: The high mortality rate among the underweight MDR-TB patients during the intensive phase of the treatment requires the nutritional support for malnourishment and ensured a close follow-up of the elderly patients with co-morbidities as well as family history of Tuberculosis. Professional Medical Publications 2023 /pmc/articles/PMC10364273/ /pubmed/37492339 http://dx.doi.org/10.12669/pjms.39.4.7025 Text en Copyright: © Pakistan Journal of Medical Sciences https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0 (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Akhtar, Abdul Majeed Kanwal, Shamsa Majeed, Sufia Majeed, Wasif Weight variation increases the risk of death during the intensive phase of treatment among MDR-TB patients: A retrospective study |
title | Weight variation increases the risk of death during the intensive phase of treatment among MDR-TB patients: A retrospective study |
title_full | Weight variation increases the risk of death during the intensive phase of treatment among MDR-TB patients: A retrospective study |
title_fullStr | Weight variation increases the risk of death during the intensive phase of treatment among MDR-TB patients: A retrospective study |
title_full_unstemmed | Weight variation increases the risk of death during the intensive phase of treatment among MDR-TB patients: A retrospective study |
title_short | Weight variation increases the risk of death during the intensive phase of treatment among MDR-TB patients: A retrospective study |
title_sort | weight variation increases the risk of death during the intensive phase of treatment among mdr-tb patients: a retrospective study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364273/ https://www.ncbi.nlm.nih.gov/pubmed/37492339 http://dx.doi.org/10.12669/pjms.39.4.7025 |
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