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Weight variation increases the risk of death during the intensive phase of treatment among MDR-TB patients: A retrospective study

OBJECTIVE: To estimate the predictors of death during intensive phase of Multidrug resistant tuberculosis treatment according to the weight of patients at the time of diagnosed. METHODS: A retrospective study was conducted at three public hospitals in the Lahore, Punjab region, namely Jinnah Hospita...

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Autores principales: Akhtar, Abdul Majeed, Kanwal, Shamsa, Majeed, Sufia, Majeed, Wasif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364273/
https://www.ncbi.nlm.nih.gov/pubmed/37492339
http://dx.doi.org/10.12669/pjms.39.4.7025
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author Akhtar, Abdul Majeed
Kanwal, Shamsa
Majeed, Sufia
Majeed, Wasif
author_facet Akhtar, Abdul Majeed
Kanwal, Shamsa
Majeed, Sufia
Majeed, Wasif
author_sort Akhtar, Abdul Majeed
collection PubMed
description OBJECTIVE: To estimate the predictors of death during intensive phase of Multidrug resistant tuberculosis treatment according to the weight of patients at the time of diagnosed. METHODS: A retrospective study was conducted at three public hospitals in the Lahore, Punjab region, namely Jinnah Hospital, Mayo Hospital and Gulab Devi Hospital on 1,496 patients receiving treatment for MDR-TB from January 2018 to December 2020. Data were collected from electronically nominating and recording system of the hospitals. Data were fitted to Cox proportional hazards regression model with 95% confidence interval (CI) to evaluate the associations between predictors of death and weight of MDR-TB patients during the intensive phase of treatment. RESULTS: This analysis revealed a MDR-TB mortality rate of 30% and the mortality rate due to MDR-TB during the intensive phase of treatment was 23%. The variables related to increased mortality among underweight patients were age more than 60 years (HR: 0.398, 95% CI: 0.314-0.504) , diabetes (HR: 1.496, 95% CI: 1.165-1.921), current smoking (HR: 0.465, 95% CI: 0.222-0.973), history of MDR-TB (HR: 0.701, 95% CI: 0.512-0.959) and culture positive at the time of diagnosed (HR: 0.499, 95% CI: 0.379-0.659) during the intensive phase of treatment. CONCLUSION: The high mortality rate among the underweight MDR-TB patients during the intensive phase of the treatment requires the nutritional support for malnourishment and ensured a close follow-up of the elderly patients with co-morbidities as well as family history of Tuberculosis.
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spelling pubmed-103642732023-07-25 Weight variation increases the risk of death during the intensive phase of treatment among MDR-TB patients: A retrospective study Akhtar, Abdul Majeed Kanwal, Shamsa Majeed, Sufia Majeed, Wasif Pak J Med Sci Original Article OBJECTIVE: To estimate the predictors of death during intensive phase of Multidrug resistant tuberculosis treatment according to the weight of patients at the time of diagnosed. METHODS: A retrospective study was conducted at three public hospitals in the Lahore, Punjab region, namely Jinnah Hospital, Mayo Hospital and Gulab Devi Hospital on 1,496 patients receiving treatment for MDR-TB from January 2018 to December 2020. Data were collected from electronically nominating and recording system of the hospitals. Data were fitted to Cox proportional hazards regression model with 95% confidence interval (CI) to evaluate the associations between predictors of death and weight of MDR-TB patients during the intensive phase of treatment. RESULTS: This analysis revealed a MDR-TB mortality rate of 30% and the mortality rate due to MDR-TB during the intensive phase of treatment was 23%. The variables related to increased mortality among underweight patients were age more than 60 years (HR: 0.398, 95% CI: 0.314-0.504) , diabetes (HR: 1.496, 95% CI: 1.165-1.921), current smoking (HR: 0.465, 95% CI: 0.222-0.973), history of MDR-TB (HR: 0.701, 95% CI: 0.512-0.959) and culture positive at the time of diagnosed (HR: 0.499, 95% CI: 0.379-0.659) during the intensive phase of treatment. CONCLUSION: The high mortality rate among the underweight MDR-TB patients during the intensive phase of the treatment requires the nutritional support for malnourishment and ensured a close follow-up of the elderly patients with co-morbidities as well as family history of Tuberculosis. Professional Medical Publications 2023 /pmc/articles/PMC10364273/ /pubmed/37492339 http://dx.doi.org/10.12669/pjms.39.4.7025 Text en Copyright: © Pakistan Journal of Medical Sciences https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0 (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Akhtar, Abdul Majeed
Kanwal, Shamsa
Majeed, Sufia
Majeed, Wasif
Weight variation increases the risk of death during the intensive phase of treatment among MDR-TB patients: A retrospective study
title Weight variation increases the risk of death during the intensive phase of treatment among MDR-TB patients: A retrospective study
title_full Weight variation increases the risk of death during the intensive phase of treatment among MDR-TB patients: A retrospective study
title_fullStr Weight variation increases the risk of death during the intensive phase of treatment among MDR-TB patients: A retrospective study
title_full_unstemmed Weight variation increases the risk of death during the intensive phase of treatment among MDR-TB patients: A retrospective study
title_short Weight variation increases the risk of death during the intensive phase of treatment among MDR-TB patients: A retrospective study
title_sort weight variation increases the risk of death during the intensive phase of treatment among mdr-tb patients: a retrospective study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364273/
https://www.ncbi.nlm.nih.gov/pubmed/37492339
http://dx.doi.org/10.12669/pjms.39.4.7025
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