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Vestibular seizures and spontaneous downbeat nystagmus of ganglioglioma origin: a case report

BACKGROUND: Low-grade gangliogliomas (GGs) are typically epileptogenic intracranial neoplasms. Yet, the presentation of simplex vertiginous experience and spontaneous downbeat nystagmus (DBN) has not been reported to date. CASE PRESENTATION: We present the case of a 26-year-old male with focal onset...

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Autores principales: Yang, Ruizhe, Wu, Haiyan, Gao, Zhiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364402/
https://www.ncbi.nlm.nih.gov/pubmed/37488495
http://dx.doi.org/10.1186/s12883-023-03311-6
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author Yang, Ruizhe
Wu, Haiyan
Gao, Zhiqiang
author_facet Yang, Ruizhe
Wu, Haiyan
Gao, Zhiqiang
author_sort Yang, Ruizhe
collection PubMed
description BACKGROUND: Low-grade gangliogliomas (GGs) are typically epileptogenic intracranial neoplasms. Yet, the presentation of simplex vertiginous experience and spontaneous downbeat nystagmus (DBN) has not been reported to date. CASE PRESENTATION: We present the case of a 26-year-old male with focal onset impaired awareness seizures, characterized by vertigo due to right temporal lobe epilepsy caused by ganglioglioma. As rare presentations, a spontaneous, consistent DBN in the absence of vertiginous experience was noticed. MRI suggested lesion in the right temporal pole. Twenty-four-hour continuous electroencephalogram (EEG) monitoring recorded periodic sharp and slow waves, originating from the right temporal lobe. The patient was completely relieved of the symptoms after surgical removal of the tumor, which was histologically confirmed as Grade I Ganglioglioma. CONCLUSIONS: Asides from the cortical pathogenesis of epileptic vertigo, this case also provides insight into the DBN secondary to tumor of the temporal lobe. Moreover, the 24-h EEG is advantageous to recognize vestibular seizures and localize the ictal onset areas. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12883-023-03311-6.
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spelling pubmed-103644022023-07-25 Vestibular seizures and spontaneous downbeat nystagmus of ganglioglioma origin: a case report Yang, Ruizhe Wu, Haiyan Gao, Zhiqiang BMC Neurol Case Report BACKGROUND: Low-grade gangliogliomas (GGs) are typically epileptogenic intracranial neoplasms. Yet, the presentation of simplex vertiginous experience and spontaneous downbeat nystagmus (DBN) has not been reported to date. CASE PRESENTATION: We present the case of a 26-year-old male with focal onset impaired awareness seizures, characterized by vertigo due to right temporal lobe epilepsy caused by ganglioglioma. As rare presentations, a spontaneous, consistent DBN in the absence of vertiginous experience was noticed. MRI suggested lesion in the right temporal pole. Twenty-four-hour continuous electroencephalogram (EEG) monitoring recorded periodic sharp and slow waves, originating from the right temporal lobe. The patient was completely relieved of the symptoms after surgical removal of the tumor, which was histologically confirmed as Grade I Ganglioglioma. CONCLUSIONS: Asides from the cortical pathogenesis of epileptic vertigo, this case also provides insight into the DBN secondary to tumor of the temporal lobe. Moreover, the 24-h EEG is advantageous to recognize vestibular seizures and localize the ictal onset areas. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12883-023-03311-6. BioMed Central 2023-07-24 /pmc/articles/PMC10364402/ /pubmed/37488495 http://dx.doi.org/10.1186/s12883-023-03311-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Yang, Ruizhe
Wu, Haiyan
Gao, Zhiqiang
Vestibular seizures and spontaneous downbeat nystagmus of ganglioglioma origin: a case report
title Vestibular seizures and spontaneous downbeat nystagmus of ganglioglioma origin: a case report
title_full Vestibular seizures and spontaneous downbeat nystagmus of ganglioglioma origin: a case report
title_fullStr Vestibular seizures and spontaneous downbeat nystagmus of ganglioglioma origin: a case report
title_full_unstemmed Vestibular seizures and spontaneous downbeat nystagmus of ganglioglioma origin: a case report
title_short Vestibular seizures and spontaneous downbeat nystagmus of ganglioglioma origin: a case report
title_sort vestibular seizures and spontaneous downbeat nystagmus of ganglioglioma origin: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364402/
https://www.ncbi.nlm.nih.gov/pubmed/37488495
http://dx.doi.org/10.1186/s12883-023-03311-6
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